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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 609 - 614 (6page)
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Purpose: Approximately 50% to 70% of women with polycystic ovary syndrome (PCOS) have some degree of insulin resistance, and obesity is known to worsen insulin resistance. Many metabolic consequences of PCOS are similar to those of obesity; therefore, defining the cause of insulin resistance in women can be difficult.
Our objective was to clarify the factors contributing to insulin resistance in PCOS. Materials and Methods: We consecutively recruited 144 women with PCOS [age: 26±5 yr, body mass index, body mass index (BMI): 24.4±4.0 kg/m2] and 145 controls (age: 25±5 yr, BMI: 23.0±3.6 kg/m2), and divided them into overweight/obese (ow/ob, BMI ≥23 kg/m2) and lean (BMI <23 kg/m2) groups. Anthropometric measures and a 75-g oral glucose tolerance test were performed, and insulin sensitivity index (ISI) was calculated as an index of insulin sensitivity. Factors predictive of ISI were determined using regression analysis. Results: ISI was significantly lower in both lean and ow/ob women with PCOS compared to BMI-matched controls (p<0.05). Increasing BMI by 1 kg/m2 decreased ISI by 0.169 in PCOS patients (p<0.05) and by 0.238 in controls (p<0.05); there was no significant difference between these groups. In lean PCOS patients and lean controls,BMI had no effect on ISI. Multiple regression analysis revealed that PCOS status (β=-0.423, p<0.001) and BMI (β=-0.375, p<0.001) were significantly associated with ISI. Conclusion: Insulin resistance is an intrinsic defect of PCOS, and a high BMI could exacerbate insulin resistance in all women, irrespective of whether they have PCOS.
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참고문헌 (22)
참고문헌 신청
Azziz R / 2006 / Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline / J Cl
Boyle JA / 2012 / Prevalence of polycystic ovary syndrome in a sample of Indigenous women in Darwin, Australia / Med J Aust 196 : 62 ~ 66
Diamanti-Kandarakis E / 1999 / A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile / J Clin Endocrinol Metab 84 : 4006 ~ 4
Dunaif A / 1987 / Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia / J Clin Endocrinol Meta
Dunaif A / 1989 / Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome / Diabetes 38 : 1165 ~ 1174
Boyle JA / 2012 / Prevalence of polycystic ovary syndrome in a sample of Indigenous women in Darwin, Australia / Med J Aust 196 : 62 ~ 66
Diamanti-Kandarakis E / 1999 / A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile / J Clin Endocrinol Metab 84 : 4006 ~ 4
Dunaif A / 1987 / Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia / J Clin Endocrinol Meta
Dunaif A / 1989 / Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome / Diabetes 38 : 1165 ~ 1174
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