지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 572 - 577 (6page)
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초록· 키워드
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Purpose: To demonstrate the significance of simultaneous electroencephalography (EEG) recording during 2-deoxy-2-[18F] fluoro-D-glucose (FDG)-positron emission tomography (PET) in childhood partial epilepsy. Materials and Methods: We included 46 children with partial epilepsy who underwent simultaneous EEG during PET. We compared the epileptogenic area of several EEG features including epileptiform discharges, focal polymorphic slow waves, and electrographic seizures, with the abnormal metabolic region on PET. We also compared the epileptogenic area of simultaneous EEG and PET with findings on magnetic resonance imaging (MRI) and video/EEG, as well as the histopathological diagnosis of the resected cortical area, in eight patients who underwent surgical resection of the epileptogenic area. Results: Hypometabolic regions on interictal PET were concordant with epileptogenic areas of epileptiform discharges and focal polymorphic slow waves, according to their frequency and/or severity, with odds ratios of 1.35 and 1.81, respectively (p<0.05). Hypermetabolic PET was also concordant with epileptogenic areas of ictal events longer than 20 seconds during the period of FDG uptake. Among the eight patients who underwent surgical resection, six patients, including two with non-lesional MRI, had concordant EEG and PET findings, were confirmed pathologically,and became seizure-free after surgery. Conclusion: Simultaneous EEG is useful in identifying epileptogenic areas due to a high concordance with abnormal PET metabolic areas. Moreover, simultaneous EEG may also prevent false lateralization of PET from postictal and mixed metabolism during ictal events, as well as abnormal hypermetabolism, during frequent interictal epileptiform discharges.
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참고문헌 (23)
참고문헌 신청
Alkonyi B / 2009 / Quantitative brain surface mapping of an electrophysiologic/metabolic mismatch in human neocortical epilepsy / Epilepsy Res 87 : 77 ~ 87
Asano E / 2004 / Is intraoperative electrocorticography reliable in children with intractable neocortical epilepsy? / Epilepsia 45 : 1091 ~ 1099
Barrington SF / 1998 / Clinical value of “ictal” FDG-positron emission tomography and the routine use of simultaneous scalp EEG studies in patients with intractable partia
Bittar RG / 1999 / Interictal spikes increase cerebral glucose metabolism and blood flow: a PET study / Epilepsia 40 : 170 ~ 178
Blumcke I / 2011 / The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Co
Asano E / 2004 / Is intraoperative electrocorticography reliable in children with intractable neocortical epilepsy? / Epilepsia 45 : 1091 ~ 1099
Barrington SF / 1998 / Clinical value of “ictal” FDG-positron emission tomography and the routine use of simultaneous scalp EEG studies in patients with intractable partia
Bittar RG / 1999 / Interictal spikes increase cerebral glucose metabolism and blood flow: a PET study / Epilepsia 40 : 170 ~ 178
Blumcke I / 2011 / The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Co
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