지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 702 - 706 (5page)
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초록· 키워드
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Purpose: Androgen replacement therapy has been shown to be safe and effective for most patients with testosterone deficiency. Male partners of infertile couples often report significantly poorer sexual activity and complain androgen deficiency symptoms. We report herein an adverse effect on fertility caused by misusage of androgen replacement therapy in infertile men with hypogonadal symptoms. Materials and Methods: The study population consisted of 8 male patients referred from a local clinic for azoospermia or severe oligozoospermia between January 2008 and July 2011. After detailed evaluation at our andrology clinic, all patients were diagnosed with iatrogenic hypogonadism associated with external androgen replacement. We evaluated changes in semen parameters and serum hormone level,and fertility status. Results: All patients had received multiple testosterone undecanoate (NebidoR) injections at local clinic due to androgen deficiency symptoms combined with lower serum testosterone level. The median duration of androgen replacement therapy prior to the development of azoospermia was 8 months (range: 4-12 months). After withdrawal of androgen therapy, sperm concentration and serum follicle-stimulating hormone level returned to normal range at a median 8.5 months (range: 7-10 months). Conclusion: Misusage of external androgen replacement therapy in infertile men with poor sexual function can cause temporary spermatogenic dysfunction, thus aggravating infertility.
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참고문헌 (16)
참고문헌 신청
Davidson JM / 1979 / Effects of androgen on sexual behavior in hypogonadal men / J Clin Endocrinol Metab 48 : 955 ~ 958
Gui YL / 2004 / Male hormonal contraception: suppression of spermatogenesis by injectable testosterone undecanoate alone or with levonorgestrel implants in chinese men / J A
Harle L / 2005 / Nebido: a long-acting injectable testosterone for the treatment of male hypogonadism / Expert Opin Pharmacother 6 : 1751 ~ 1759
Jan Z / 2012 / Reversible testosterone-induced azoospermia in a 45-year-old man attending an infertility outpatient clinic / Andrologia 44 (1) : 823 ~ 825
Lenzi A / 2003 / Stress, sexual dysfunctions, and male infertility / J Endocrinol Invest 26 (3) : 72 ~ 76
Gui YL / 2004 / Male hormonal contraception: suppression of spermatogenesis by injectable testosterone undecanoate alone or with levonorgestrel implants in chinese men / J A
Harle L / 2005 / Nebido: a long-acting injectable testosterone for the treatment of male hypogonadism / Expert Opin Pharmacother 6 : 1751 ~ 1759
Jan Z / 2012 / Reversible testosterone-induced azoospermia in a 45-year-old man attending an infertility outpatient clinic / Andrologia 44 (1) : 823 ~ 825
Lenzi A / 2003 / Stress, sexual dysfunctions, and male infertility / J Endocrinol Invest 26 (3) : 72 ~ 76
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