지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 707 - 714 (8page)
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Purpose: Guinea pig is one of the most suitable animal models for Mycobacterium tuberculosis (M. tb) infection since it shows similarities to pulmonary infection in humans. Although guinea pig shows hematogenous spread of M. tb infection into the whole body, immunological studies have mainly focused on granulomatous tissues in lungs and spleens. In order to investigate the time-course of disease pathogenesis and immunological profiles in each infected organ, we performed the following approaches with guinea pigs experimentally infected with M. tb over a 22-week post-infection period. Materials and Methods: We examined body weight changes, M. tb growth curve, cytokine gene expression (IFN-γ and TNF-α), and histopathology in liver, spleen, lungs and lymph nodes of infected guinea pigs. Results:The body weights of infected guinea pigs did not increase as much as uninfected ones and the number of M. tb bacilli in their organs increased except bronchotracheal lymph node during the experimental period. The gene expression of IFN-γ and TNF-α was induced between 3 and 6 weeks of infection; however, kinetic profiles of cytokine gene expression showed heterogeneity among organs over the study period. Histophathologically granulomatous lesions were developed in all four organs of infected guinea pigs. Conclusion: Although IFN-γ and TNF-α gene expression profiles showed heterogeneity, the granuloma formation was clearly observed in every organ regardless of whether the number of bacilli increased or decreased.
However, this protective immunity was accompanied with severe tissue damage in all four organs, which may lead to the death of guinea pigs.
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참고문헌 (25)
참고문헌 신청
/ 1992 / Tuberculosis control and research strategies for the 1990s: memorandum from a WHO meeting / Bull World Health Organ 70 : 17 ~ 21
/ 1996 / Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi
Ahmad Z / 2011 / Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models / J Antimicrob Chemother 66 :
Barry CE 3rd / 2010 / The chemical biology of new drugs in the development for tuberculosis / Curr Opin Chem Biol 14 : 456 ~ 466
Chan ED / 2008 / Multidrug-resistant and extensively drug-resistant tuberculosis: a review / Curr Opin Infect Dis : 587 ~ 595
/ 1996 / Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi
Ahmad Z / 2011 / Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models / J Antimicrob Chemother 66 :
Barry CE 3rd / 2010 / The chemical biology of new drugs in the development for tuberculosis / Curr Opin Chem Biol 14 : 456 ~ 466
Chan ED / 2008 / Multidrug-resistant and extensively drug-resistant tuberculosis: a review / Curr Opin Infect Dis : 587 ~ 595
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