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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 650 - 657 (8page)
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Purpose: ROS1 is an oncogene, expressed primarily in glioblastomas of the brain that has been hypothesized to mediate the effects of early stage tumor progression. In addition, it was reported that ROS1 expression was observed in diverse cancer tissue or cell lines and ROS1 is associated with the development of several tumors. However, ROS1 expression has not been studied in breast cancer to date. Therefore,we investigated ROS1 expression at the protein and gene level to compare expression patterns and to verify the association with prognostic factors in invasive ductal carcinoma (IDC) of the breast. Materials and Methods: Tissue samples from 203 patients were used. Forty-six cases were available for fresh tissue. We performed immunohistochemical staining and real-time polymerase chain reaction (PCR). Results: ROS1 expression was significantly lower in proportion to higher histologic grade, higher mitotic counts, lower estrogen receptor expression, and a higher Ki-67 proliferation index, although ROS1 expression was not significantly associated with the survival rate. The result of real-time PCR revealed similar trends, however not statistically significant. Conclusion: Higher ROS1 expression may be associated with favorable prognostic factors of IDC and its expression in IDC is related to the proliferation of tumor cells.
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참고문헌 (28)
참고문헌 신청
Miglietta L / 2010 / Prognostic value of estrogen receptor and Ki-67 index after neoadjuvant chemotherapy in locally advanced breast cancer expressing high levels of proliferation at diagnosis / Oncology 79:255~261
Yasuda H / 2012 / Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer / J Thorac Oncol 7:1086~1090
Takeuchi K / 2012 / RET, ROS1 and ALK fusions in lung cancer / Nat Med 18:378~381
Acquaviva J / 2009 / The multifaceted roles of the receptor tyrosine kinase ROS in development and cancer / Biochim Biophys Acta 1795 : 37 ~ 52
Bergethon K / 2012 / ROS1 rearrangements define a unique molecular class of lung cancers / J Clin Oncol 30 : 863 ~ 870
Yasuda H / 2012 / Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer / J Thorac Oncol 7:1086~1090
Takeuchi K / 2012 / RET, ROS1 and ALK fusions in lung cancer / Nat Med 18:378~381
Acquaviva J / 2009 / The multifaceted roles of the receptor tyrosine kinase ROS in development and cancer / Biochim Biophys Acta 1795 : 37 ~ 52
Bergethon K / 2012 / ROS1 rearrangements define a unique molecular class of lung cancers / J Clin Oncol 30 : 863 ~ 870
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