지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 223 - 229 (7page)
이용수
초록· 키워드
오류제보하기
Lipopolysaccharide (LPS), given in vivo, modulates opossum esophageal motor functions by inducing the inducible nitric oxide synthase (iNOS), which increases nitric oxide (NO) production. Superoxide, a NO scavenger, is generated during this endotoxemia. Superoxide is cleared by superoxide dismutase (SOD) and catalase (CAT) to protect the physiological function of NO. This study examined whether lower esophageal sphincter (LES) motility, NO release, and iNOS and nitrotyrosine accumulation in the LES are affected by LPS in vitro. Muscle strips from the opossum LES were placed in tissue baths containing oxygenated Krebs buffer. NO release was measured with a chemiluminescence NOx analyzer, and Western blots were performed to analyze iNOS and nitrotyrosine production. The percent change in resting LES tone after a 6-hour exposure to LPS was significantly increased compared to pretreatment values. The percent LES relaxation upon electrical stimulation was significantly decreased in the control group at 6 hours, indicating that the LPS treatment had an effect. The NO concentration in the tissue bath of LPS- treated muscle without nerve stimulation was significantly less than that of LPS treatment combined with SOD/CAT or SOD/CAT alone. iNOS and nitrotyrosine were detectable and increased over time in the LES muscle of both the control and LPS-treated groups. Antioxidant enzymes may play a role in regulating NO-mediated neuromuscular functions in the LES.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
/ / Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion : 683 ~ 8
/ / effect on tone relaxation and cGMP content of the lower esophageal sphincter
/ 1995 / Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis 109 : 1475 ~ 1483
/ 1996 / Antioxidant enzymes in intramural nerves of the opossum esophagus 270 : G136 ~ G142
/ 1996 / IL-1 stimulates superoxide and delayed peroxynitrite production by pulmonary vascular smooth muscle cells 271 : L932 ~ L938
/ / effect on tone relaxation and cGMP content of the lower esophageal sphincter
/ 1995 / Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis 109 : 1475 ~ 1483
/ 1996 / Antioxidant enzymes in intramural nerves of the opossum esophagus 270 : G136 ~ G142
/ 1996 / IL-1 stimulates superoxide and delayed peroxynitrite production by pulmonary vascular smooth muscle cells 271 : L932 ~ L938
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Protein Kinase C-αRegulates Toll-like Receptor 4-Mediated Inducible Nitric Oxide Synthase Expression
대한구강악안면외과학회지
2008 .01
-
Pretreatment of Low-Dose and Super-Low-Dose LPS on the Production of In Vitro LPS-Induced Inflammatory Mediators
Toxicological Research
2018 .01
-
PC12 세포주에서 Lipopolysaccharide/Tumor Necrosis Factor-α/Interferon-γ로 유도된 Inducible Nitric Oxide Synthase 발현과 세포자멸사
Journal of Pathology and Translational Medicine
2002 .01
-
Expression of Hepatic Vascular Stress Genes Following Ischemiai/Reperfusion and Subsequent Endotoxemia
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
Lipopolysaccharide/Interferon-gamma에 의한C6 Glioma 세포주의 Nitric Oxide 생성 양상과Dexamethasone의 억제효과
Journal of Pathology and Translational Medicine
2002 .01
-
쥐 해마의 Lipopolysaccharide 국소주입에 의한 Tumor Necrosis Factor-α, Interleukin-1β 및 Inducible Nitric Oxide Synthase의 발현
Journal of Pathology and Translational Medicine
2004 .01
-
Two acyl phenol glucosides as Inhibitors of iNOS from Popolus davidiana in LPS- activated macrophages
대한약학회 학술대회
2003 .01
-
p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Regulate Nitric Oxide Production and Inflammatory Cytokine Expression in Raw Cells
Immune Network
2005 .03
-
RAW 264.7 Cell에서 세이지에 의한 염증성 Cytokine 및 iNOS억제 효과
약학회지
2004 .01
-
The involvement of benzodiazepine receptor on the relaxation of cat lower esophageal sphincter tone
대한약학회 학술대회
2002 .01
-
Anti-inflammatory Effects of Ethanol Extract of Chinese Medicinal Plants in Yanjin on LPS-stimulated RAW 264.7 Macrophages
대한본초학회지(본초분과학회지)
2018 .01
-
미세분진이 흰쥐의 폐포대식세포에서 Nitric Oxide 생성 및 iNOS 발현과 Nitrotyrosilated-protein의 형성에 미치는 효과
Tuberculosis and Respiratory Diseases
2006 .01
-
백굴채(白屈菜)의 물추출물이 lipopolysaccharide로 유도된 Nitric Oxide의 생성 및 iNOS와 COX-2의 발현에 미치는 영향
대한한의학방제학회지
2004 .01
-
Wogonin, a flavone from Scutellaria radix, inhibits nitric oxide production from RAW 264.7 cells
한국응용약물학회 추계학술발표논문집
1998 .01
-
리포다당질에 의한 급성폐손상에서 Ethyl Pyruvate의 효과
Tuberculosis and Respiratory Diseases
2006 .01
-
Inhibitors of Inducible Nitric Oxide Synthase Expression from Artemisia iwayomogi
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
荊芥蓮翹湯이 lipopolysaccharide로 유도된 nitric oxide의 생성 및 iNOS와 COX-2의 발현, cytokine에 미치는 영향
동의생리병리학회지
2007 .04
-
Immunohictochemical Expression of Inducible Nitric Oxide Synthase on the LPS-induced Shock and Wound Healing in Rats
해부·생물인류학
1999 .12
-
Lichen Planus Is an Uncommon Cause of Nonspecific Proximal Esophageal Inflammation
Gut and Liver
2013 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0