지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 116 - 122 (7page)
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Purpose: To evaluate the efficacy of carcinoembryonic antigen (CEA) measurement for monitoring tumor progression during palliative chemotherapy in metastatic colorectal cancer. Materials and Methods: Forty-eight patients with initially unresectable metastatic colorectal cancer (n=26, 54.2%) or recurrent unresectable metastatic colorectal cancer (n=22, 45.8%) received FOLFOX-4 chemotherapy for palliation. Serum CEA levels and carbohydrate antigen 19-9 levels were measured and computed tomography (CT) studies were performed prior to chemotherapy and after 3 cycles of chemotherapy. From the CT images, tumor responses were evaluated according to the Response Evaluation Criteria in Solid Tumors criteria and categorized as complete response, partial response, stable disease, and progressive disease. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of tumor marker assessments for determining tumor response were calculated. Results: The sensitivity, specificity and diagnostic accuracy of CEA assessment for prediction of disease progression were 50%, 77% and 69%, respectively. When the patients were dichotomized according to baseline CEA level, the initially elevated CEA group showed higher sensitivity and higher diagnostic accuracy compared to the initially normal CEA group (sensitivity=67% vs. 20%; diagnostic accuracy=71% vs. 62%). Conclusion: CEA assessment could be useful for monitoring tumor progression during palliative chemotherapy in only patients with initially elevated CEA level.
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참고문헌 (17)
참고문헌 신청
Allen-Mersh TG / 1987 / Significance of a fall in serum CEA concentration in patients treated with cytotoxic chemotherapy for disseminated colorectal cancer / Gut 28 : 1625
Andre T / 2004 / Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer / N Engl J Med 350 : 2343 ~ 2351
Douillard JY / 2000 / Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomise
Duffy MJ / 2001 / Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful? / Clin Chem 47 : 624 ~ 630
Eisenhauer EA / 2009 / New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) / Eur J Cancer 45 : 228 ~ 247
Andre T / 2004 / Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer / N Engl J Med 350 : 2343 ~ 2351
Douillard JY / 2000 / Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomise
Duffy MJ / 2001 / Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful? / Clin Chem 47 : 624 ~ 630
Eisenhauer EA / 2009 / New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) / Eur J Cancer 45 : 228 ~ 247
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