지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1,085 - 1,092 (8page)
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Purpose: Plasma neurotrophin-3 (NT-3) levels are associated with several neural disorders. We previously reported that neurotrophins were released from salivary glands following acute immobilization stress. While the salivary glands were the source of plasma neurotrophins in that situation, the association between the expression of neurotrophins and the salivary gland under chronic stress conditions is not well understood. In the present study, we investigated whether NT-3 levels in the salivary gland and plasma were influenced by chronic stress. Materials and Methods: Expressions of NT-3 mRNA and protein were characterized, using real-time polymerase chain reactions, enzyme-linked immunosorbent assay, and immunohistochemistry,in the submandibular glands of male rats exposed to chronic stress (12 h daily for 22 days). Results: Plasma NT-3 levels were significantly increased by chronic stress (p<0.05), and remained elevated in bilaterally sialoadenectomized rats under the same condition. Since chronic stress increases plasma NT-3 levels in the sialoadenectomized rat model, plasma NT-3 levels were not exclusively dependent on salivary glands. Conclusion: While the salivary gland was identified in our previous study as the source of plasma neurotrophins during acute stress, the exposure to long-term stress likely affects a variety of organs capable of releasing NT-3 into the bloodstream. In addition, the elevation of plasma NT-3 levels may play important roles in homeostasis under stress conditions.
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참고문헌 (24)
참고문헌 신청
Aloe L / 1986 / Aggressive behavior induces release of nerve growth factor from mouse salivary gland into the bloodstream / Proc Natl Acad Sci U S A 83 : 6184 ~ 6187
Artico M / 2008 / Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis / Oncol Rep 20 : 1201 ~ 1206
Cohen S / 1960 / Purification of a nerve-growth promoting protein from the mouse salivary gland and its neuro-cytotoxic antiserum / Proc Natl Acad Sci U S A 46 : 302 ~ 311
Cohen S. / 1962 / Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal / J Biol Chem 237 : 1555 ~ 1562
De Simone R / 1990 / Nerve growth factor released into the bloodstream following intraspecific fighting induces mast cell degranulation in adult male mice / Brain Behav Immun
Artico M / 2008 / Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis / Oncol Rep 20 : 1201 ~ 1206
Cohen S / 1960 / Purification of a nerve-growth promoting protein from the mouse salivary gland and its neuro-cytotoxic antiserum / Proc Natl Acad Sci U S A 46 : 302 ~ 311
Cohen S. / 1962 / Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal / J Biol Chem 237 : 1555 ~ 1562
De Simone R / 1990 / Nerve growth factor released into the bloodstream following intraspecific fighting induces mast cell degranulation in adult male mice / Brain Behav Immun
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