지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1,073 - 1,080 (8page)
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Purpose: Standard treatment of asymptomatic spinal cord hemangioblastoma in von Hippel-Lindau (VHL) disease has yet to be established. The purpose of this study was to propose guidelines for the treatment of asymptomatic spinal cord hemangioblastomas in VHL disease. Materials and Methods: VHL disease patients treated for spinal cord hemangioblastomas between 1999 and 2009 were included. All spinal cord hemangioblastomas were divided into three groups: Group 1, asymptomatic tumors at initial diagnosis followed with serial imaging studies; Group 2, asymptomatic tumors at initial diagnosis that were subsequently resected; and Group 3, symptomatic tumors at initial diagnosis, all of which were resected. Results: We identified 24 spinal cord hemangioblastomas in 12 patients. Groups 1, 2 and 3 comprised 13, 4 and 7 tumors, respectively. Group 1 exhibited a smaller tumor volume (257.1 mm³) and syrinx size (0.8 vertebral columns) than those of Group 2 (1304.5 mm³, 3.3 vertebral columns) and Group 3 (1787.4 mm³, 6.1 vertebral columns). No difference in tumor volume or syrinx size was observed between Groups 2 and 3. Five tumors in Group 1 were resected during follow-up because symptoms had developed or the tumor had significantly grown. Finally, among 17 asymptomatic tumors at the initial diagnosis, nine tumors were resected. Only one tumor of these nine tumors resulted in neurological deficits, while five of seven symptomatic tumors caused neurological deficits. Conclusion: Selective resection of asymptomatic tumors before they cause neurological deficits might bring about better outcomes.
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참고문헌 (28)
참고문헌 신청
Ammerman JM / 2006 / Long-term natural history of hemangioblastomas in patients with von Hippel-Lindau disease: implications for treatment / J Neurosurg 105 : 248 ~ 255
Bohling T / 1996 / Expression of growth factors and growth factor receptors in capillary hemangioblastoma / J Neuropathol Exp Neurol 55 : 522 ~ 527
Bostrom A / 2008 / Intramedullary hemangioblastomas: timing of surgery, microsurgical technique and follow-up in 23 patients / Eur Spine J 17 : 882 ~ 886
Conway JE / 2001 / Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease / Neurosurgery 48 : 55 ~ 62
Dwarakanath S / 2008 / Intraspinal hemangioblastoma: analysis of 22 cases / J Clin Neurosci 15 : 1366 ~ 1369
Bohling T / 1996 / Expression of growth factors and growth factor receptors in capillary hemangioblastoma / J Neuropathol Exp Neurol 55 : 522 ~ 527
Bostrom A / 2008 / Intramedullary hemangioblastomas: timing of surgery, microsurgical technique and follow-up in 23 patients / Eur Spine J 17 : 882 ~ 886
Conway JE / 2001 / Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease / Neurosurgery 48 : 55 ~ 62
Dwarakanath S / 2008 / Intraspinal hemangioblastoma: analysis of 22 cases / J Clin Neurosci 15 : 1366 ~ 1369
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