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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1,211 - 1,215 (5page)
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Metabolic syndrome is an important long term complication in chronic asymptomatic HIV-infected subjects under highly active antiretroviral therapy (HAART), because it can contribute to morbidity and mortality via cardiovascular disease (CVD). Therefore, a predictive marker for early detection of metabolic syndrome may be necessary to prevent CVD in HIV-infected subjects. Retinol-binding protein-4 (RBP-4) has been shown to be associated with metabolic syndrome in various non-HIV-infected populations. We performed a cross-sectional study to evaluate whether serum RBP-4 levels are correlated with metabolic syndrome in HIV-infected subjects receiving HAART. In total, 98 HIV-infected Koreans who had been receiving HAART for at least 6 months were prospectively enrolled. Metabolic syndrome was diagnosed according to the Adult Treatment Panel III criteria, and serum RBP-4 concentrations were measured using human RBP-4 sandwich enzyme-linked immunosorbent assay. Serum RBP-4 levels were significantly higher in HIV-infected subjects receiving HAART with metabolic syndrome (n=33, 33.9±7.7 μg/mL) than in those without it (n=65, 29.9±7.2 μg/mL) (p=0.012). In multivariate linear regression analysis, the number of components of metabolic syndrome presented and waist circumference were independently, significantly correlated with RBP-4 (p=0.018 and 0.030, respectively). In conclusion, we revealed a strong correlation between RBP-4 and the number of components of metabolic syndrome in HIV-infected subjects receiving HAART.
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참고문헌 (19)
참고문헌 신청
Aeberli I / 2007 / Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children / J
Barbaro G. / 2006 / Highly active antiretroviral therapy-associated metabolic syndrome: pathogenesis and cardiovascular risk / Am J Ther 13 : 248 ~ 260
Bonfanti P / 2007 / HIV and metabolic syndrome: a comparison with the general population / J Acquir Immune Defic Syndr 45 : 426 ~ 431
Bozzette SA / 2003 / Cardiovascular and cerebrovascular events in patients treated for human immunodeficiency virus infection / N Engl J Med 348 : 702 ~ 710
Estrada V / 2006 / Lipodystrophy and metabolic syndrome in HIV-infected patients treated with antiretroviral therapy / Metabolism 55 : 940 ~ 945
Barbaro G. / 2006 / Highly active antiretroviral therapy-associated metabolic syndrome: pathogenesis and cardiovascular risk / Am J Ther 13 : 248 ~ 260
Bonfanti P / 2007 / HIV and metabolic syndrome: a comparison with the general population / J Acquir Immune Defic Syndr 45 : 426 ~ 431
Bozzette SA / 2003 / Cardiovascular and cerebrovascular events in patients treated for human immunodeficiency virus infection / N Engl J Med 348 : 702 ~ 710
Estrada V / 2006 / Lipodystrophy and metabolic syndrome in HIV-infected patients treated with antiretroviral therapy / Metabolism 55 : 940 ~ 945
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