지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 990 - 998 (9page)
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초록· 키워드
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Purpose: Dendritic cell (DC) vaccination for melanoma was introduced because melanoma carries distinct tumor-associated antigens. The purpose of this study was to investigate the efficacy and safety of DC vaccination for melanoma in Korea.
Materials and Methods: Five patients with stage IV and one with stage II were enrolled. Autologous monocyte-derived DCs (MoDCs) were cultured and pulsed with tumor-lysate, keyhole limpet hemocyanin, and cytokine cocktail for mature antigen-loaded DC. DC vaccination was repeated four times at 2-week intervals and 2-4×10^7 DC were injected each time. Results: Reduced tumor volume was observed by PET-CT in three patients after DC vaccination. Delayed type hypersensitivity responses against tumor antigen were induced in five patients. Tumor antigen-specific IFN-γ-producing peripheral blood mononuclear cells were detected with enzyme-linked immunosorbent spot in two patients. However, the overall clinical outcome showed disease progression in all patients. Conclusion: In this study, DC vaccination using tumor antigen-loaded, mature MoDCs led to tumor regression in individual melanoma patients. Further standardization of DC vaccination protocol is required to determine which parameters lead to better anti-tumor responses and clinical outcomes.
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참고문헌 (21)
참고문헌 신청
Attia P / 2005 / Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with m
Curiel TJ / 2004 / Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival / Nat Med 10 : 942 ~ 949
Dannull J / 2005 / Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells / J Clin Invest 115 : 3623 ~ 3633
Eubel J / 2009 / Dendritic cell vaccination as a treatment modality for melanoma / Expert Rev Anticancer Ther 9 : 1631 ~ 1642
Hall HI / 1999 / Update on the incidence and mortality from melanoma in the United States / J Am Acad Dermatol 40 : 35 ~ 42
Curiel TJ / 2004 / Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival / Nat Med 10 : 942 ~ 949
Dannull J / 2005 / Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells / J Clin Invest 115 : 3623 ~ 3633
Eubel J / 2009 / Dendritic cell vaccination as a treatment modality for melanoma / Expert Rev Anticancer Ther 9 : 1631 ~ 1642
Hall HI / 1999 / Update on the incidence and mortality from melanoma in the United States / J Am Acad Dermatol 40 : 35 ~ 42
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