지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 967 - 971 (5page)
이용수
초록· 키워드
오류제보하기
Purpose: To investigate the direct relationship between the follicular fluid (FF) level of soluble human leukocyte antigen G (HLA-G) and fertilizability of the corresponding oocyte as well as the morphological quality of the corresponding embryo. Materials and Methods: Sixty-three patients were stimulated with recombinant FSH combined with gonadotropin-releasing hormone (GnRH) agonist long (n=5) or antagonist protocol (n=58) for standard in vitro fertilization (IVF). At the time oocyte retrieval, follicular fluid was obtained from single dominant follicle in 63 patients, and the level of soluble HLA-G was measured by sandwich enzyme-liked immunosorbent assay (ELISA). Normal fertilization and individual embryo quality were evaluated, and were graded to four categories by morphological criteria (the embryo with symmetrical blastomeres and no fragmentation were assigned as grade A). Good-quality embryo was defined as those with grade A or B. Results: Soluble HLA-G was not detected in 15 FF samples. In the group with positive FF soluble HLA-G (sHLA-G) (n=48), high levels of sHLA-G (>117.758 U/mL) could predict the failure of fertilization with statistical significance {area under the curve (AUC) 0.676, 95% confidence interval (CI) 0.525-0.804}. However, the FF sHLA-G level was not related with the formation of good-quality embryo. Conclusion: High level of FF sHLA-G could predict the fertilization failure of the corresponding oocyte, but was not related with the formation of good-quality embryo.
목차
등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Choi YS / 2009 / Efficacy of ER-alpha polymorphisms and the intrafollicular IGF system for predicting pregnancy in IVF-ET patients / Gynecol Obstet Invest 67 : 73 ~ 80
Hviid TV / 2006 / HLA-G in human reproduction: aspects of genetics, function and pregnancy complications / Hum Reprod Update 12 : 209 ~ 232
LeMaoult J / 2003 / Biology and functions of human leukocyte antigen-G in health and sickness / Tissue Antigens 62 : 273 ~ 284
Mendoza C / 1999 / Relationship between fertilization results after intracytoplasmic sperm injection, and intrafollicular steroid, pituitary hormone and cytokine concentrati
Pfeiffer KA / 2000 / Soluble HLA levels in early pregnancy after in vitro fertilization / Hum Immunol 61 : 559 ~ 564
Hviid TV / 2006 / HLA-G in human reproduction: aspects of genetics, function and pregnancy complications / Hum Reprod Update 12 : 209 ~ 232
LeMaoult J / 2003 / Biology and functions of human leukocyte antigen-G in health and sickness / Tissue Antigens 62 : 273 ~ 284
Mendoza C / 1999 / Relationship between fertilization results after intracytoplasmic sperm injection, and intrafollicular steroid, pituitary hormone and cytokine concentrati
Pfeiffer KA / 2000 / Soluble HLA levels in early pregnancy after in vitro fertilization / Hum Immunol 61 : 559 ~ 564
이 논문의 저자 정보
최근 본 자료
댓글(0)
0