지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 488 - 494 (7page)
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초록· 키워드
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Purpose: Our previous study indicated that the presence of wheat-specific IgG1 and IgG4 antibodies was associated with work-related symptoms in workers exposed to wheat flour. We performed this study to investigate the genetic polymorphisms of β_2-adrenergic receptors and wheat-specific antibodies in association with the clinical parameters of baker’s asthma. Materials and Methods: In total, 379 subjects working in a single industrial bakery were enrolled in this study. The skin prick test was performed with common inhalant allergens and wheat flour extract. The presence of serum-specific IgE, IgG1, and IgG4 antibodies to wheat flour were determined by ELISA. Whole blood samples were obtained for genotype analysis. Subjects were genotyped with regard to five candidate single nucleotide polymorphisms (SNPs) of the β_2-adrenergic receptor gene (ADRB2; -47 T>C, 46 A>G, 79 C>G, 252 G>A, and 523 C>A) using a single-base extension method. Results: No significant associations were observed between the genotype/allele frequencies of any of the SNPs tested and any clinical parameters. The haplotype of ADRB2 (GAA composed of 46 A>G, 252 G>A, and 523 C>A) was significantly associated with work-related symptoms (p<0.05). Moreover, in subjects with the AG or GG genotype at 46 A>G and haplotype [GAA] of ADRB2, the prevalence rates of wheat-specific IgG1 antibodies and lower respiratory symptoms increased significantly with exposure intensity (both p<0.05). Conclusion: The findings of the present study suggest that ADRB2 genetic polymorphism may contribute to the development of work-related symptoms in workers exposed to wheat flour, which can lead to baker’s asthma.
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참고문헌 (25)
참고문헌 신청
Bahn JW / 2006 / Sensitization to Empynase(pronase B) in exposed hospital personnel and identification of the Empynase allergen / Clin Exp Allergy 36 : 352 ~ 358
Battais F / 2003 / Food allergy to wheat: identification of immunogloglin E and immunoglobulin G-binding proteins with sequential extracts and purified proteins from wheat f
Baur X / 1998 / Baker’s asthma: still among the most frequent occupational respiratory disorders / J Allergy Clin Immunol 102 : 984 ~ 997
Baur X / 1999 / Baker’s asthma: causes and prevention / Int Arch Occup Environ Health 72 : 292 ~ 296
Bernstein IL / 1999 / Asthma in the workplace. 2nd ed / Marcel Dekker Inc
Battais F / 2003 / Food allergy to wheat: identification of immunogloglin E and immunoglobulin G-binding proteins with sequential extracts and purified proteins from wheat f
Baur X / 1998 / Baker’s asthma: still among the most frequent occupational respiratory disorders / J Allergy Clin Immunol 102 : 984 ~ 997
Baur X / 1999 / Baker’s asthma: causes and prevention / Int Arch Occup Environ Health 72 : 292 ~ 296
Bernstein IL / 1999 / Asthma in the workplace. 2nd ed / Marcel Dekker Inc
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