지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 482 - 487 (6page)
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초록· 키워드
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Purpose: Cryptococcal meningitis is a relatively common opportunistic infection in human immunodeficiency virus (HIV) patients and it can frequently occur in immunocompetent hosts without any apparent underlying disease. Nevertheless, little is known about cyptococcal meningitis in the Korean population. The purpose of this study was to evaluate the clinical features and initial laboratory findings of cryptococcal meningitis in patients with and without HIV at a tertiary care teaching hospital. Materials and Methods: We performed a retrospective study at a tertiary care teaching hospital from January 2001 to December 2009. Eleven HIV positive patients and nine HIV negative patients were included. Results: The most common symptoms were headache and fever in cryptococcal meningitis, and diabetic mellitus,end stage renal disease and liver cirrhosis were the main associated conditions in patients without HIV. Patients with HIV showed lower peripheral CD4+ cell counts (median: 9, range: 1-107) and a higher burden of cryptococcus than patients without HIV. There were no statistically significant differences in serum CRP level and other cerebrospinal fluid parameters between patients with HIV and without HIV. The in-hospital mortality was 10%, and recurrence of cyptococcal meningitis was observed in 3 patients with HIV and this occurred within 5 months of the first episode. Conclusion: Cryptococcal meningitis is fatal without treatment, therefore, rapid recognition of symptoms such as fever and headache and diagnosis is required to decrease the mortality. Recurrence of meningitis after treatment should carefully be followed up, especially in advanced HIV patients.
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참고문헌 (19)
참고문헌 신청
Bicanic T / 2005 / Cryptococcal meningitis / Br Med Bull 72 : 99 ~ 118
Brouwer AE / 2004 / Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomized trial / Lancet 363 : 1764 ~ 1767
Choi KG / 1984 / A clinical study of cryptococcal infection / J Korean Neurol Assoc 2 : 14 ~ 20
Cox GM / 1997 / Cryptococcus neoformans var neoformans and gattii and Trichosporon species. In Topley and Wilson’s Microbiology and Microbial Infections, 9th ed / Arnold Press
Crowe SM / 1991 / Predictive value of CD4 lymphocyte numbers for the development of opportunistic infections and malignancies in HIV infected persons / J Acquir Immune Defic
Brouwer AE / 2004 / Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomized trial / Lancet 363 : 1764 ~ 1767
Choi KG / 1984 / A clinical study of cryptococcal infection / J Korean Neurol Assoc 2 : 14 ~ 20
Cox GM / 1997 / Cryptococcus neoformans var neoformans and gattii and Trichosporon species. In Topley and Wilson’s Microbiology and Microbial Infections, 9th ed / Arnold Press
Crowe SM / 1991 / Predictive value of CD4 lymphocyte numbers for the development of opportunistic infections and malignancies in HIV infected persons / J Acquir Immune Defic
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