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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 522 - 526 (5page)
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Helicobacter pylori (H. pylori) is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. Proteinase-activated receptor 2 (PAR2), subgroup of G-protein coupled receptor family, is highly expressed in gastric cancer, and chronic expression of cyclooxygenase-2 (COX-2) plays an important role in H. pylori-associated gastric carcinogenesis and inflammation. We previously demonstrated that H. pylori induced the expression of PAR2 and COX-2 in gastric epithelial cells. Present study aims to investigate whether COX-2 expression induced by H. pylori in Korean isolates is mediated by PAR2 via activation of Gi protein and Src kinase in gastric epithelial AGS cells. Results showed that H. pylori-induced COX-2 expression was inhibited in the cells transfected with antisense oligonucleotide for PAR2 or treated with Gi protein blocker pertussis toxin, Src kinase inhibitor herbimycin A and soybean trypsin inbitor, indicating that COX-2 expression is mediated by PAR2 through activation of Gi protein and Src kinase in gastric epithelial cells infected with H. pylori in Korean isolates. Thus, targeting the activation of PAR2 may be beneficial for prevention or treatment of gastric inflammation and carcinogenesis associated with H. pylori infection.
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참고문헌 (22)
참고문헌 신청
/ 200905 / Proteinase-Activated Receptor-2 Mediates the Expression of Integrin alpha(5) and beta(1) in Helicobacter pylori-Infected Gastric Epithelial AGS Cells / Digestion 8
Bach S / 2002 / Gene expression profiling in AGS cells stimulated with Helicobacter pylori isogenic strains (cagA positive or cagA negative) / Infect Immun 70 : 988 ~ 992
Blaser MJ / 1995 / Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach / Cancer Res 5
Boolbol SK / 1996 / Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis / Cancer Res 56 : 2556 ~ 2
Coughlin SR / 2003 / PARticipation in inflammation / J Clin Invest 111 : 25 ~ 27
Bach S / 2002 / Gene expression profiling in AGS cells stimulated with Helicobacter pylori isogenic strains (cagA positive or cagA negative) / Infect Immun 70 : 988 ~ 992
Blaser MJ / 1995 / Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach / Cancer Res 5
Boolbol SK / 1996 / Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis / Cancer Res 56 : 2556 ~ 2
Coughlin SR / 2003 / PARticipation in inflammation / J Clin Invest 111 : 25 ~ 27
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