지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 796 - 802 (7page)
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초록· 키워드
오류제보하기
Purpose: Physicians and oncology nurses must continue to update their knowledge on treatment and treatmentrelated
side effects, while searching for effective methods to prevent or manage side effects. The objective of our
study was to describe the incidence and response to treatment of the hand-foot syndrome (HFS) and the compliance
with treatment of patients with stage IIB, IIIA, IIIB, and IIIC colon cancer that were treated with capecitabine alone
as adjuvant therapy. Materials and Methods: Between September 2005 and September 2006, 84 patients fulfilled
the inclusion criteria and were included in this retrospective analysis of prospectively collected data. Results: The
treatment compliance rate was 90.5% (76 out of the 84 patients). The HFS developed in 65 patients (77.4%).
Thirty-three patients (50.7%) had grade 1 HFS, 22 patients (33.8%) had grade 2 HFS and 10 patients (15.5%) had
grade 3 HFS, as their most severe episode. For Grade 1 patients, the dose was maintained, and skin barrier cream
and moist exposed burn ointment (MEBO) were applied. For Grade 2 patients, either the dose was maintained or
25% of the dose was reduced; MEBO and supportive care were provided. For Grade 3 patients, one cycle of
chemotherapy was interrupted followed by dose adjustment; MEBO and supportive care were provided.
Conclusion: HFS is manageable if both patients and oncology care teams are educated about HFS associated with
capecitabine. The HFS is treated by patient education, preventive management, ointment application, conservative
management, dose reduction, and interruption of chemotherapy administration.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Asgari MM / 1999 / Expression and localization of thymidine phosphorylase/ platelet-derived endothelial cell growth factor in skin and cutaneous tumors / J Cutan Pathol 26 :
Ayanian JZ / 2003 / Use of adjuvant chemotherapy and radiation therapy for colorectal cancer in a population-based cohort / J Clin Oncol 21 : 1293 ~ 2300
Baack BR / 1991 / Chemotherapy-induced acral erythema / J Am Acad Dermatol 24 : 457 ~ 461
Benson AB 3rd / 2004 / American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer / J Clin Oncol 22 : 3408 ~ 3419
Blum JL / 1999 / Multicenter phase II study of capecitabine in paclitaxelrefractory metastatic breast cancer / J Clin Oncol 17 : 485 ~ 493
Ayanian JZ / 2003 / Use of adjuvant chemotherapy and radiation therapy for colorectal cancer in a population-based cohort / J Clin Oncol 21 : 1293 ~ 2300
Baack BR / 1991 / Chemotherapy-induced acral erythema / J Am Acad Dermatol 24 : 457 ~ 461
Benson AB 3rd / 2004 / American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer / J Clin Oncol 22 : 3408 ~ 3419
Blum JL / 1999 / Multicenter phase II study of capecitabine in paclitaxelrefractory metastatic breast cancer / J Clin Oncol 17 : 485 ~ 493
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