지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 354 - 358 (5page)
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초록· 키워드
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TNF-related apoptosis inducing ligand (TRAIL) expressions were studied in primary human brain astrocytes in response to pro-inflammatory cytokines. When astrocytes were treated with IL-1β, TNF-α or IFN-γ, TRAIL was induced in cultured fetal astrocytes. In particular, IFN-γ induced the highest levels of TRAIL in cultured astrocytes. When astrocytes were pre- reated with IFN-γ, they induced apoptosis in TRAIL-sensitive Peer cells. Our results suggest that IFN-γ modulates the expression of TRAIL in astrocytes, which may enhance cytotoxic sensitivity of infiltrating immune cells or brain cells other than astrocytes during inflammation of brain.
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참고문헌 (18)
참고문헌 신청
/ 1995 / Cytokine regulation of astrocyte function: in-vitro studies using cells from the human brain 13 : 265 ~ 274
/ 1995 / Identification and characterization of a new member of the TNF family that induces apoptosis 3 : 673 ~ 682
/ 1996 / Apoptosis induced by HIV-1 infection of the central nervous system 98 : 1979 ~ 1990
/ 1996 / Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain 84 : 1513 ~ 1518
/ 1999 / Ex-pression of TRAIL and its receptors in human brain tumors 257 : 454 ~ 459
/ 1995 / Identification and characterization of a new member of the TNF family that induces apoptosis 3 : 673 ~ 682
/ 1996 / Apoptosis induced by HIV-1 infection of the central nervous system 98 : 1979 ~ 1990
/ 1996 / Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain 84 : 1513 ~ 1518
/ 1999 / Ex-pression of TRAIL and its receptors in human brain tumors 257 : 454 ~ 459
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