지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 545 - 552 (8page)
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초록· 키워드
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Purpose: The purpose of the present study was to investigate whether electrical stimulation (ES) improves the paralytic effect of botulinum toxin type A (BTX-A) and evaluate the differences between low frequency (LF) and high frequency (HF) ES in children with spastic diplegic cerebral palsy (CP). Materials and Methods: Twenty-three children with spastic diplegia CP who had BTX-A injections into both gastrocnemius muscles were assessed. Following the toxin injection, electrical stimulation was given to 1 side of the injected muscles and a sham-stimulation to the other side for 30 min a day for 7 consecutive days [HFES (25Hz) to 11 children, LFES (4Hz) to 12 children]. The compound motor action potentials (CMAP) from the gastrocnemius muscle were assessed before injection and at 5 time points (days 3, 7, 14, 21, and 30) after injection. The clinical assessments of spasticity were performed before and 30 days after injection. Results: The CMAP area became significantly lower in both LFES and HFES sides from 3 days after injection compared to baseline values. In other words, the CMAP area of the sham-stimulated side showed a significant decrease at 7 or 14 days after injection. However, there were no significant differences in clinical assessment of spasticity between the stimulated and sham-stimulated sides. Conclusion: Short-term ES in both LF and HF to the spastic muscles injected with BTX-A might induce earlier denervating action of BTX-A. However, it does not necessarily lead to clinical and electrophysiological benefits in terms of reduction of spasticity.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
[학술
Aoki KR / 2001 / Botulinum toxin type A and other botulinum toxin serotypes: a comparative review ofbiochemical and pharmacological actions / Eur J Neurol 8 (5) : 21 ~ 29
Corry IS / 1995 / Use of a motion analysis laboratory in assessing the effects of botulinum toxin in a cerebral palsy [dissertation] / 박사 / The Queens University
Cosgrove AP / 1994 / Botulinum toxin A prevents the development of contractures in the hereditary spastic mouse / Dev Med Child Neurol 36 : 379 ~ 385
Das Gupta BR / 1972 / Role of a protease in natural activation of Clostridium botulinum neurotoxin / Infect Immun 6 : 587 ~ 590
Aoki KR / 2001 / Botulinum toxin type A and other botulinum toxin serotypes: a comparative review ofbiochemical and pharmacological actions / Eur J Neurol 8 (5) : 21 ~ 29
Corry IS / 1995 / Use of a motion analysis laboratory in assessing the effects of botulinum toxin in a cerebral palsy [dissertation] / 박사 / The Queens University
Cosgrove AP / 1994 / Botulinum toxin A prevents the development of contractures in the hereditary spastic mouse / Dev Med Child Neurol 36 : 379 ~ 385
Das Gupta BR / 1972 / Role of a protease in natural activation of Clostridium botulinum neurotoxin / Infect Immun 6 : 587 ~ 590
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