Visually Estimated MRI Targeted Prostate Biopsy Could Improve the Detection of Significant Prostate Cancer in Patients with a PSA Level <10 ng/mL

Chung Moon Kee; 이동훈; 남종길; 박성우; 이승우; 한지연; 이상돈; 이준우

Visually Estimated MRI Targeted Prostate Biopsy Could Improve the Detection of Significant Prostate Cancer in Patients with a PSA Level <10 ng/mL

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Type: Academic journal

Author: Chung Moon Kee 이동훈 남종길 박성우 이승우 한지연 이상돈 이준우

Journal: Yonsei University College of Medicine Yonsei Medical Journal Yonsei Medical Journal 제57권 제3호 KCI Accredited Journals

Published: 2016.1

Pages: 565 - 571 (7page)

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Visually Estimated MRI Targeted Prostate Biopsy Could Improve the Detection of Significant Prostate Cancer in Patients with a PSA Level <10 ng/mL

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Purpose: To compare prostate cancer detection rates between 12 cores transrectal ultrasound-guided prostate biopsy (TRUS-Bx) and visually estimated multiparametric magnetic resonance imaging (mp-MRI)-targeted prostate biopsy (MRI-visual-Bx) for patientswith prostate specific antigen (PSA) level less than 10 ng/mL. Materials and Methods: In total, 76 patients with PSA levels below 10 ng/mL underwent 3.0 Tesla mp-MRI and TRUS-Bx prospectivelyin 2014. In patients with abnormal lesions on mp-MRI, we performed additional MRI-visual-Bx. We compared pathologic results,including the rate of clinically significant prostate cancer cores (cancer length greater than 5 mm and/or any Gleason grade greater than 3 in the biopsy core). Results: The mean PSA was 6.43 ng/mL. In total, 48 of 76 (63.2%) patients had abnormal lesions on mp-MRI, and 116 targeted biopsycores, an average of 2.42 per patient, were taken. The overall detection rates of prostate cancer using TRUS-Bx and MRI-visual-Bx were 26/76 (34.2%) and 23/48 (47.9%), respectively. In comparing the pathologic results of TRUS-Bx and MRI-visual-Bx cores, the positive rates were 8.4% (77 of 912 cores) and 46.6% (54 of 116 cores), respectively (p<0.001). Mean cancer core lengths and mean cancer core percentages were 3.2 mm and 24.5%, respectively, in TRUS-Bx and 6.3 mm and 45.4% in MRI-visual-Bx (p<0.001). In addition,Gleason score ≥7 was noted more frequently using MRI-visual-Bx (p=0.028). The detection rate of clinically significant prostate cancer was 27/77 (35.1%) and 40/54 (74.1%) for TRUS-Bx and MRI-visual-Bx, respectively (p<0.001). Conclusion: MRI-visual-Bx showed better performance in the detection of clinically significant prostate cancer, compared to TRUS-Bx among patients with a PSA level less than 10 ng/mL.

#Prostate cancer #prostate biopsy #magnetic resonance imaging

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References (33)

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Elabbady AA / 2006 / Extended 12-core prostate biopsy increases both the detection of prostate cancer and the accuracy of Gleason score / Eur Urol 49:49~53

Eichler K / 2006 / Diagnostic value of systematic biopsy methods in the investigation of prostate cancer: a systematic review / J Urol 175:1605~1612

Pepe P / 2007 / Saturation prostate needle biopsy and prostate cancer detection at initial and repeat evaluation / Urology 70:1131~1135

Heidenreich A / 2013 / Early detection of prostate cancer: European Association of Urology recommendation / Eur Urol 64:347~354

Ukimura O / 2013 / Contemporary role of systematic prostate biopsies: indications, techniques, and implications for patient care / Eur Urol 63:214~230

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