지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 599 - 605 (7page)
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Purpose: To correlate tumor stiffness and lymphangiogenesis in breast cancer and to find its clinical implications.
Materials and Methods: A total of 140 breast cancer patients were evaluated. Tumor stiffness was quantitatively measured by shear-wave elastography in preoperative ultrasound examination, calculated as mean elasticity value (kPa). Slides of resected breast cancer specimens were reviewed for most fibrotic area associated with tumor. D2-40 immunohistochemical staining was applied for fibrotic areas to detect the lymphatic spaces. Microlymphatic density, tumor stiffness, and clinicopathologic data were analyzed.
Results: Higher elasticity value was associated with invasive size of tumor, microlymphatic density, histologic grade 3, absence of extensive intraductal component, presence of axillary lymph node metastasis, and Ki-67 labeling index (LI) in univariate regressionanalysis, and associated with Ki-67 LI and axillary lymph node metastasis in multivariate regression analysis. Microlymphaticdensity was associated histologic grade 3, mean elasticity value, and Ki-67 LI in univariate regression analysis. In multivariate regression analysis, microlymphatic density was correlated with mean elasticity value.
Conclusion: In breast cancer, tumor stiffness correlates with lymphangiogenesis and poor prognostic factors.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
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Fukumura D / 1998 / Tumor induction of VEGF promoter activity in stromal cells / Cell 94:715~725
Liu L / 2010 / Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis / Clin Cancer Res 16:2740~2750
Zhang Q / 2013 / Wnt/β-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling / Carcinogenesis 34:962~973
Van den Eynden GG / 2007 / A fibrotic focus is a prognostic factor and a surrogate marker for hypoxia and (lymph)angiogenesis in breast cancer: review of the literature and proposal on the criteria of evaluation / Histopathology 51:440~451
Fukumura D / 1998 / Tumor induction of VEGF promoter activity in stromal cells / Cell 94:715~725
Liu L / 2010 / Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis / Clin Cancer Res 16:2740~2750
Zhang Q / 2013 / Wnt/β-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling / Carcinogenesis 34:962~973
Van den Eynden GG / 2007 / A fibrotic focus is a prognostic factor and a surrogate marker for hypoxia and (lymph)angiogenesis in breast cancer: review of the literature and proposal on the criteria of evaluation / Histopathology 51:440~451
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