지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1,297 - 1,302 (6page)
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초록· 키워드
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Purpose: Impaired cardiovascular autonomic regulation is a non-motor symptom of Parkinson’s disease (PD) and may increase long-term morbidity. This study appliedfrequency-domain analysis of heart rate variability (HRV) to understand the progression of sympathetic and parasympathetic cardiac regulation in patients with PD. Materials and Methods: In this cross-sectional study, 21 male and 11 female Taiwanese patients with advanced PD and 32 healthy gender- and age-matched subjects were enrolled. To minimize artifacts due to subject motion, daytime electrocardiogramsfor 5 minutes were recorded in awake patients during levodopa-on periods and controls. Using fast Fourier transformation, heart rate variables were quantified into a high-frequency power component [0.15--0.45 Hz, considered to reflect vagal (parasympathetic) regulation], low-frequency power component (0.04--0.15 Hz, reflecting mixed sympathetic and parasympathetic regulation), and low-frequency power in normalized units (reflecting sympathetic regulation). The significance of between-group differences was analyzed using the paired t-test. Pearson correlation analysis and stepwise regression analysis were applied to assessthe correlation of patient age, PD duration, and disease severity (represented by the Unified Parkinson’s Disease Rating Scale) with each heart rate variables. Results: Impaired HRV is significantly correlated with the duration of PD, but not with disease severity and patient age. Meanwhile, parasympathetic heart rate variableis more likely than sympathetic heart rate variable to be affected by PD. Conclusion:PD is more likely to affect cardiac parasympathetic regulation than sympatheticregulation by time and the heart rate variables have the association with Parkinsonian motor symptom duration.
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참고문헌 (22)
참고문헌 신청
/ 1996 / Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North Amer
/ 2011 / Enhanced catecholamine transporter binding in the locus coeruleus of patients with early Parkinson disease / BMC Neurol 11 : 88 ~
Benarroch EE / 2000 / Involvement of the ventrolateral medulla in parkinsonism with autonomic failure / Neurology 54 : 963 ~ 968
Bouhaddi M / 2004 / Impaired cardiovascular autonomic control in newly and long-term-treated patients with Parkinson’s disease: involvement of L-dopa therapy / Auton Neuros
Byrne EA / 1996 / Role of aerobic capacity and body mass index in the age-associated decline in heart rate variability / J Appl Physiol (1985) 81 : 743 ~ 750
/ 2011 / Enhanced catecholamine transporter binding in the locus coeruleus of patients with early Parkinson disease / BMC Neurol 11 : 88 ~
Benarroch EE / 2000 / Involvement of the ventrolateral medulla in parkinsonism with autonomic failure / Neurology 54 : 963 ~ 968
Bouhaddi M / 2004 / Impaired cardiovascular autonomic control in newly and long-term-treated patients with Parkinson’s disease: involvement of L-dopa therapy / Auton Neuros
Byrne EA / 1996 / Role of aerobic capacity and body mass index in the age-associated decline in heart rate variability / J Appl Physiol (1985) 81 : 743 ~ 750
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