지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1,430 - 1,435 (6page)
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Purpose: We evaluated the incidence and risk factors of postoperative nausea and vomiting (PONV) in patients with fentanyl-based intravenous patient-controlled analgesia (IV-PCA) and single antiemetic prophylaxis of 5-hydroxytryptamine type 3 (5 HT3)-receptor antagonist after the general anesthesia. Materials and Methods: In this retrospective study, incidence and risk factors for PONV were evaluated with fentanyl IV-PCA during postoperative 48 hours after various surgeries. Results: Four hundred-forty patients (23%) of 1878 had showed PONV. PCA was discontinued temporarily in 268 patients (14%), mostly due to PONV (88% of 268 patients). In multivariate analysis, female, non-smoker, history of motion sickness or PONV, long duration of anesthesia (>180 min), use of desfluraneand intraoperative remifentanil infusion were independent risk factors for PONV. If one, two, three, four, five, or six of these risk factors were present, the incidences of PONV were 18%, 19%, 22%, 31%, 42%, or 50%. Laparoscopic surgeryand higher dose of fentanyl were not risk factors for PONV. Conclusion: Despiteantiemetic prophylaxis with 5 HT3-receptor antagonist, 23% of patients with fentanyl-based IV-PCA after general anesthesia showed PONV. Long duration of anesthesia and use of desflurane were identified as risk factors, in addition to risk factors of Apfel’s score (female, non-smoker, history of motion sickness or PONV). Also, intraoperative remifentanil infusion was risk factor independent of postoperative opioid use. As the incidence of PONV was up to 50% according to the number of risk factors, risk-adapted, multimodal or combination therapy should be applied.
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참고문헌 (22)
참고문헌 신청
Apfel CC / 1999 / A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers / Anesthesiology 91 : 693 ~
Apfel CC / 2002 / Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design / Br J Anaest
Apfel CC / 2003 / Risk assessment of postoperative nausea and vomiting / Int Anesthesiol Clin 41 : 13 ~ 32
Choi YS / 2008 / Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondanset
Duck Hwan Choi / 2005 / A Korean Predictive Model for Postoperative Nausea and Vomiting / Journal of Korean Medical Science 20 (5) : 811 ~ 815
Apfel CC / 2002 / Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design / Br J Anaest
Apfel CC / 2003 / Risk assessment of postoperative nausea and vomiting / Int Anesthesiol Clin 41 : 13 ~ 32
Choi YS / 2008 / Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondanset
Duck Hwan Choi / 2005 / A Korean Predictive Model for Postoperative Nausea and Vomiting / Journal of Korean Medical Science 20 (5) : 811 ~ 815
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