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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 413 - 418 (6page)
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초록· 키워드
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This study was designed to investigate the effects of iron supplementation on the parameters of oxidative stress in the skeletal muscle tissue of hyperthyroidism induced rats. Hyperthyroidism was found to cause an increase in thiobarbituric acid-reactive substances (TBARS) and copper zinc superoxide dismutase (Cu, Zn SOD) activity, but decreases in the glutathione-peroxidase (GSH Px) activity and glutathione (GSH). Iron supplementation caused an increase in TBARS and a decrease in GSH. Iron supplementation in hyperthyroid rats attenuated the hyperthyroid state, but lowered the plasma ferritin level, which is considered an indicator of thyroid hormone action. Iron supplementation caused no additional increase in the TBARS in hyperthyroid rats, ameliorated the decrease in GSH content and abolished the induction of Cu, Zn SOD.
Our findings suggested no increase, but a decrease, in the risk of oxidative stress in iron supplemented hyperthyroid rats. Whether supplementation of iron would have similar effects in humans should be further investigated in clinical studies.
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참고문헌 (29)
참고문헌 신청
/ 1951 / Protein measurement with the Folin reagent 193 : 265 ~ 275
/ 1963 / Improved method for the determination of blood glutathione 51 : 882 ~ 888
/ 1967 / Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase 70 : 158 ~ 169
/ 1969 / Anemia in hyperthyroidism 70 : 507 ~ 516
/ 1977 / Comparative study of superoxide dismutase, catalase and glutathione peroxidase levels in erythrocytes of different animals 22 : 1525 ~ 1535
/ 1963 / Improved method for the determination of blood glutathione 51 : 882 ~ 888
/ 1967 / Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase 70 : 158 ~ 169
/ 1969 / Anemia in hyperthyroidism 70 : 507 ~ 516
/ 1977 / Comparative study of superoxide dismutase, catalase and glutathione peroxidase levels in erythrocytes of different animals 22 : 1525 ~ 1535
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