지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 174 - 179 (6page)
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Purpose: This study was designed to investigate the effect of detrusor overactivity induced by partial bladder outlet obstruction (BOO) on the expression of aquaporin 1 (AQP1) and caveolin 1 (CAV1) in the rat urinary bladder, and to determine the role of these molecules in detrusor overactivity.
Methods: Female Sprague-Dawley rats were divided into control (n=30) and experimental (n=30) groups. The BOO group underwent partial BOO, and the control group underwent a sham operation. After 4 weeks, an urodynamic study was performed to measure the contraction interval and contraction pressure. The expression and cellular localization of AQP1 and CAV1 were determined by western blot and immunofluorescence experiments in the rat urinary bladder.
Results: In cystometrograms, the contraction interval was significantly lower in the BOO group (2.9±1.5 minutes) than in the control group (6.7±1.0 minutes) (P<0.05). Conversely, the average contraction pressure was significantly higher in the BOO group (21.2±3.3 mmHg) than in the control group (13.0±2.5 mmHg) (P<0.05). AQP1 and CAV1 were coexpressed in the capillaries, arterioles, and venules of the suburothelial layer. AQP1 and CAV1 protein expression was significantly increased in the BOO rats compared to the control rats (P<0.05).
Conclusions: Detrusor overactivity induced by BOO causes a significant increase in the expression of AQP1 and CAV1, which were coexpressed in the suburothelial microvasculature. This finding suggests that AQP1 and CAV1 might be closely related to bladder signal activity and may have a functional role in BOO-associated detrusor overactivity.
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참고문헌 (24)
참고문헌 신청
Araki I / 2004 / Overexpression of epithelial sodium channels in epithelium of human urinary bladder with outlet obstruction / Urology 64 : 1255 ~ 1260
Birder LA / 2007 / Mechanisms of disease: involvement of the urothelium in bladder dysfunction / Nat Clin Pract Urol 4 : 46 ~ 54
Cao G / 2003 / Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis / Am J Pathol 162 : 1241 ~ 1248
Chang S / 2009 / Alteration of the PKC-mediated signaling pathway for smooth muscle contraction in obstruction-induced hypertrophy of the urinary bladder / Lab Invest 89 : 82
Cristofaro V / 2007 / Smooth muscle caveolae differentially regulate specific agonist induced bladder contractions / Neurourol Urodyn 26 : 71 ~ 80
Birder LA / 2007 / Mechanisms of disease: involvement of the urothelium in bladder dysfunction / Nat Clin Pract Urol 4 : 46 ~ 54
Cao G / 2003 / Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis / Am J Pathol 162 : 1241 ~ 1248
Chang S / 2009 / Alteration of the PKC-mediated signaling pathway for smooth muscle contraction in obstruction-induced hypertrophy of the urinary bladder / Lab Invest 89 : 82
Cristofaro V / 2007 / Smooth muscle caveolae differentially regulate specific agonist induced bladder contractions / Neurourol Urodyn 26 : 71 ~ 80
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