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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 159 - 168 (10page)
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초록· 키워드
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Recent efforts in the generation of large genomics, transcriptomics, proteomics, metabolomics and other types of ‘omics’ data sets have provided an unprecedentedly detailed view of certain diseases, however to date most of this literature has been focused on malignancy and other lethal pathological conditions. Very little intensive work on global profiles has been performed to understand the molecular mechanism of interstitial cystitis/painful bladder syndrome/bladder pain syndrome (IC/PBS/BPS), a chronic lower urinary tract disorder characterized by pelvic pain, urinary urgency and frequency, which can lead to long lasting adverse effects on quality of life. A lack of understanding of molecular mechanism has been a challenge and dilemma for diagnosis and treatment, and has also led to a delay in basic and translational research focused on biomarker and drug discovery, clinical therapy, and preventive strategies against IC/PBS/BPS. This review describes the current state of ‘omics’ studies and available data sets relevant to IC/PBS/BPS, and presents opportunities for new research directed at understanding the pathogenesis of this complex condition.
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참고문헌 (78)
참고문헌 신청
Kim J / 2007 / p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells / FEBS Lett 581:3795~3799
Keay S / 2008 / Cell signaling in interstitial cystitis/painful bladder syndrome / Cell Signal 20:2174~2179
김자영 / 2011 / Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome / International Neurourology Journal 15(4):184~191
Yang W / 2011 / Quantitative Proteomics Identifies a beta-Catenin Network as an Element of the Signaling Response to Frizzled-8 Protein-Related Antiproliferative Factor / MOLECULAR & CELLULAR PROTEOMICS 10(0000000006)
Kim J / 2011 / An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor / In Vitro Cell Dev Biol Anim 47:2~9
Keay S / 2008 / Cell signaling in interstitial cystitis/painful bladder syndrome / Cell Signal 20:2174~2179
김자영 / 2011 / Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome / International Neurourology Journal 15(4):184~191
Yang W / 2011 / Quantitative Proteomics Identifies a beta-Catenin Network as an Element of the Signaling Response to Frizzled-8 Protein-Related Antiproliferative Factor / MOLECULAR & CELLULAR PROTEOMICS 10(0000000006)
Kim J / 2011 / An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor / In Vitro Cell Dev Biol Anim 47:2~9
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