지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 164 - 170 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence. In Marfan syndrome, which is associated with mutations in Fibrillin-1, pelvic floor disorders are commonly observed. We hypothesize that Fibrillin-1 gene expression is altered in pelvic organ prolapse.
Methods: Thirty women undergoing colporrhaphy or hysterectomy because of cystocele, rectocele, cystorectocele, or uterine prolapse were assigned to a pelvic prolapse study group, and thirty women undergone hysterectomy for nonpelvic prolapse conditions were assigned to a control group. Real-time polymerase chain reaction was conducted on vaginal tissue samples to measure the expression of Fibrillin-1. Expression levels were compared between study and control groups by Mann-Whitney U test with Bonferroni revision.
Results: Fibrillin-1 gene expression was not significantly lower in the study group than in the control group. Similarly, no significant correlation between Fibrillin-1 levels and grade of pelvic prolapse was found. Age over 40 years (P=0.018) and menopause (P=0.027) were both associated with reduced Fibrillin-1 levels in the pelvic prolapse group, whereas the delivery of babies weighing over 3,500 g at birth was associated with increased Fibrillin-1 expression (P=0.006).
Conclusions: The results did not indicate a significant reduction in Fibrillin-1 gene expression in pelvic prolapse disorders; however, reduced Fibrillin-1 may contribute to increased pelvic organ prolapse risk with age and menopause. Increased Fibrillin- 1 gene expression may be a compensatory mechanism in cases of delivery of babies with high birth weight. Further studies are needed for a better understanding of these observations.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Jelovsek JE / 2007 / Pelvic organ prolapse / Lancet 369:1027~1038
Wu JM / 2014 / Lifetime risk of stress urinary incontinence or pelvic organ prolapse surgery / Obstet Gynecol 123:1201~1206
Kerkhof MH / 2009 / Changes in connective tissue in patients with pelvic organ prolapse: a review of the current literature / Int Urogynecol J Pelvic Floor Dysfunct 20:461~474
Sandberg LB / 1971 / Structural features of tropoelastin related to the sites of cross-links in aortic elastin / Biochemistry 10:52~56
Ramirez F / 2004 / Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology / Physiol Genomics 19:151~154
Wu JM / 2014 / Lifetime risk of stress urinary incontinence or pelvic organ prolapse surgery / Obstet Gynecol 123:1201~1206
Kerkhof MH / 2009 / Changes in connective tissue in patients with pelvic organ prolapse: a review of the current literature / Int Urogynecol J Pelvic Floor Dysfunct 20:461~474
Sandberg LB / 1971 / Structural features of tropoelastin related to the sites of cross-links in aortic elastin / Biochemistry 10:52~56
Ramirez F / 2004 / Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology / Physiol Genomics 19:151~154
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Identification of a Fibrillin-1 Gene Mutation in a Monozygotic Twin Presenting with Bilateral Juvenile- onset Ectopia Lentis
Korean Journal of Ophthalmology
2015 .01
-
Effect of Pelvic Compression Belt on Abdominal Muscle Activity, Pelvic Rotation and Pelvic Tilt During Active Straight Leg Raise
한국전문물리치료학회지
2019 .01
-
Laparoscopic Pelvic Organ Prolapse Surgery
대한외과학회 학술대회 초록집
2020 .11
-
Prepare for Aging Society: How to Select an Appropriate Treatment for Pelvic Organ Prolapse in Elderly Women
대한외과학회 학술대회 초록집
2022 .11
-
Various Approaches and Treatments for Pelvic Organ Prolapse in Women
대한폐경학회지
2018 .01
-
The Integral Theory, Pelvic Floor Biomechanics, and Binary Innervation
International Neurourology Journal
2024 .09
-
Management of Pelvic Bone Injury
대한외과학회 학술대회 초록집
2022 .11
-
Pelvic Floor Disorder
대한외과학회 학술대회 초록집
2015 .11
-
Pelvic Floor Disorder (Incontinence, Rectal Prolapse)
대한외과학회 학술대회 초록집
2016 .11
-
뼈 검사 영상과 골반 X선 영상의 결합 유용성 평가
핵의학기술
2018 .01
-
Surgical technique of en bloc pelvic resection for advanced ovarian cancer
Journal of Gynecologic Oncology
2015 .01
-
A Study on the Mortality of Patients with Pelvic Fractures
대한외과학회 학술대회 초록집
2017 .11
-
분만방법 유형이 골반바닥근육 기능에 미치는 영향
PNF and movement
2017 .01
-
The Immediate Effects of Posterior Pelvic Tilt with Taping on Pelvic Inclination, Gait Function and Balance in Chronic Stroke Patients
대한물리의학회지
2017 .01
-
Pelvic Injury in Multiple Trauma Patients
대한외과학회 학술대회 초록집
2022 .11
-
Sex Difference in the Range of Pelvic Tilt in Sitting and Standing Among Korean Young Adults
한국전문물리치료학회지
2020 .01
-
Comparison of sexual function between sacrocolpopexy and sacrocervicopexy
Obstetrics & Gynecology Science
2017 .01
-
골반교정 치료효과의 국내 임상 연구 경향에 대한 체계적 문헌 고찰
대한예방한의학회지
2021 .01
-
골반 골절에 한방재활치료를 적용한 증례 보고 및 보존적 치료에 대한 국내 문헌 분석
한방재활의학과학회지
2018 .01
-
Complex Pelvic-perineal Soft Tissue Infection Management in Open Pelvic Fractures: Comparison between Conventional and Modified Instillation Negative-pressure Wound Therapy
대한외과학회 학술대회 초록집
2022 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0