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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 4 (4page)
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Introduction: The measurement of flow-mediated dilatation (FMD) via ultrasound has been established as a reliable non-invasive measurement of endothelial function. However, the guidelines mention nothing regarding diurnal variation of FMD. Thus, we investigated the FMD in healthy people and diurnal variation of FMD.
Methods: Twenty-five apparently healthy persons participated in this study. All participants had no history of cardiovascular diseases, hypertension, or diabetes and used any medication. For each volunteer, the measurements were repeated in the morning and afternoon on two different days. We checked capillary blood glucose, total cholesterol, triglyceride, high-density lipoprotein (HDL), and low-density lipoprotein (LDL)-cholesterol.
Results: The average of FMD measurements was 8.45% ± 2.39%. The mean values of systolic and diastolic blood pressure, heart rate, lipid profiles, and glucose levels were similar between the morning and afternoon measurements after 9-h fasting. There was no significant difference of FMD measurements between the morning and afternoon (8.32% ± 2.27% and 8.58% ± 2.56%, p = 0.329). Moreover, there was significant correlation between FMD in the morning and afternoon (r = 0.856, p < 0.001).
Conclusions: Our study shows measurement of FMD was 8.45% in healthy Koreans. Also, there was no significant difference of FMD measurements between the morning and afternoon.
Keywords: Flow-mediated dilatation, Diurnal variation, Circadian variation
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참고문헌 (24)
참고문헌 신청
Bae JH. / 1998 / The effect of vitamin E on the endothelial function following a single high-fat meal in normal subject, patients with coronary heart disease and patients wi
Bonetti PO. / 2003 / Endothelial dysfunction. A marker of atherosclerotic risk / Arterioscler Thromb Vasc Bio 23 : 168 ~ 175
Corretti MC. / 2002 / Guidelines for the ultrasound assessment of endothelialdependent flow-mediated vasodilation of the brachial artery : a report of the International brach
Donald AE. / 2008 / Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation / J Am Coll Cardiol 51 : 1959 ~ 1964
Drexler H. / 1992 / Endothelial function in chronic congestive heart failure / Am J Cardiol 69 : 1596 ~ 1601
Bonetti PO. / 2003 / Endothelial dysfunction. A marker of atherosclerotic risk / Arterioscler Thromb Vasc Bio 23 : 168 ~ 175
Corretti MC. / 2002 / Guidelines for the ultrasound assessment of endothelialdependent flow-mediated vasodilation of the brachial artery : a report of the International brach
Donald AE. / 2008 / Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation / J Am Coll Cardiol 51 : 1959 ~ 1964
Drexler H. / 1992 / Endothelial function in chronic congestive heart failure / Am J Cardiol 69 : 1596 ~ 1601
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