지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 368 - 375 (8page)
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초록· 키워드
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Background/Aims: This study evaluated the predictors of spontaneous viral clearance (SVC), as defined by twoconsecutive undetectable hepatitis C virus (HCV) RNA tests performed ≥12 weeks apart, and the outcomes of acutehepatitis C (AHC) demonstrating SVC or treatment-induced viral clearance.
Methods: Thirty-two patients with AHC were followed for 12-16 weeks without administering antiviral therapy.
Results: HCV RNA was undetectable at least once in 14 of the 32 patients. SVC occurred in 12 patients (37.5%), amongwhom relapse occurred in 4. SVC was exhibited in 8 of the 11 patients exhibiting undetectable HCV RNA within 12 weeks.
HCV RNA reappeared in three patients (including two patients with SVC) exhibiting undetectable HCV RNA after 12weeks. SVC was more frequent in patients with low viremia than in those with high viremia (55.6% vs. 14.3%; P =0.02),and in patients with HCV genotype non-1b than in those with HCV genotype 1b (57.1% vs. 22.2%; P=0.04). SVC was morecommon in patients with a ≥2 log reduction of HCV RNA at 4 weeks than in those with a smaller reduction (90% vs. 9.1%,P<0.001). A sustained viral response was achieved in all patients (n=18 ) receiving antiviral therapy.
Conclusions: Baseline levels of HCV RNA and genotype non-1b were independent predictors for SVC. A ≥2 log reductionof HCV RNA at 4 weeks was a follow-up predictor for SVC. Undetectable HCV RNA occurring after 12 weeks was notsustained. All patients receiving antiviral therapy achieved a sustained viral response. Antiviral therapy should beinitiated in patients with detectable HCV RNA at 12 weeks after the diagnosis.
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참고문헌 (25)
참고문헌 신청
Alberti A / 2002 / Therapy of acute hepatitis C / Hepatology 36 (5 Suppl 1) : S195 ~ S200
Alter MJ / 1992 / The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team / N Engl J Med
Armstrong GL / 2006 / The prevalence of hepatitis C virus infection in the United States, 1999 through 2002 / Ann Intern Med 144 : 705 ~ 714
Beinhardt S / 2012 / Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection / Gastroenterology 142 : 78 ~ 85
Beinhardt S / 2013 / A diagnostic score for the prediction of spontaneous resolution of acute hepatitis C virus infection / J Hepatol 59 : 972 ~ 977
Alter MJ / 1992 / The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team / N Engl J Med
Armstrong GL / 2006 / The prevalence of hepatitis C virus infection in the United States, 1999 through 2002 / Ann Intern Med 144 : 705 ~ 714
Beinhardt S / 2012 / Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection / Gastroenterology 142 : 78 ~ 85
Beinhardt S / 2013 / A diagnostic score for the prediction of spontaneous resolution of acute hepatitis C virus infection / J Hepatol 59 : 972 ~ 977
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