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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 47 - 55 (9page)
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Background/Aims: The modification of the Model for End-Stage Liver Disease (MELD) scoring system (Refit MELD)and the modification of MELD-Na (Refit MELDNa), which optimized the MELD coefficients, were published in 2011. Weaimed to validate the superiority of the Refit MELDNa over the Refit MELD for the prediction of 3-month mortality inKorean patients with cirrhosis and ascites.
Methods: We reviewed the medical records of patients admitted with hepatic cirrhosis and ascites to the KonkukUniversity Hospital between January 2006 and December 2011. The Refit MELD and Refit MELDNa were comparedusing the predictive value of the 3-month mortality, as assessed by the Child-Pugh score.
Results: In total, 530 patients were enrolled, 87 of whom died within 3 months. Alcohol was the most commonetiology of their cirrhosis (n=271, 51.1%), and the most common cause of death was variceal bleeding (n=20, 23%).
The areas under the receiver operating curve (AUROCs) for the Child-Pugh, Refit MELD, and Refit MELDNa scores were0.754, 0.791, and 0.764 respectively; the corresponding values when the analysis was performed only in patientswith persistent ascites (n=115) were 0.725, 0.804, and 0.796, respectively. The significant difference found among theChild-Pugh, Refit MELD, and Refit MELDNa scores was between the Child-Pugh score and Refit MELD in patients withpersistent ascites (P=0.039).
Conclusions: Refit MELD and Refit MELDNa exhibited good predictability for 3-month mortality in patients withcirrhosis and ascites. However, Refit MELDNa was not found to be a better predictor than Refit MELD, despite theknown relationship between hyponatremia and mortality in cirrhotic patients with ascites.
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참고문헌 (16)
참고문헌 신청
Arroyo V / 1996 / Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis / Hepatology 23 : 164 ~ 176
Biggins SW / 2006 / Evidence-based incorporation of serum sodium concentration into MELD / Gastroenterology 130 : 1652 ~ 1660
Chang TT / 2010 / Longterm entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B / Hepa
Freeman RB Jr / 2002 / The new liver allocation system: Moving toward evidence-based transplantation policy / Liver Transpl 8 : 851 ~ 858
Heuman DM / 2004 / Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death / Hepatology 40 : 802 ~ 8
Biggins SW / 2006 / Evidence-based incorporation of serum sodium concentration into MELD / Gastroenterology 130 : 1652 ~ 1660
Chang TT / 2010 / Longterm entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B / Hepa
Freeman RB Jr / 2002 / The new liver allocation system: Moving toward evidence-based transplantation policy / Liver Transpl 8 : 851 ~ 858
Heuman DM / 2004 / Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death / Hepatology 40 : 802 ~ 8
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