메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background/Aims: Lipid profile and insulin resistance (IR) are associated with hepatitis C virus (HCV) and may predictthe chronic hepatitis C (CHC) treatment response. The aim of this study was to determine the association betweenCHC treatment response and lipid profile and IR change during treatment. Methods: In total, 203 CHC patients were reviewed retrospectively between January 2005 and December 2011 atSoon Chun Hyang University Hospital. The lipid profile, homeostasis model for assessment (HOMA) of IR (HOMA-IR),and HOMA of β cells (HOMA-β) were evaluated before interferon plus ribavirin therapy (BTx), at the end of treatment(DTx), and 24 weeks after the end of treatment (ATx). Results: A sustained virologic response (SVR) was achieved by 81% of all patients (49/60), 60% (n=36) of whompossessed genotype 1, with the remainder being non-genotype-1 (40%, n=24). Apart from age, which wassignificantly higher in the non-SVR group (SVR, 48.0±11.2 years, mean±SD; non-SVR, 56.6±9.9 years; P<0.01), therewere no significant differences in the baseline characteristics between the SVR and non-SVR groups. In the SVR group,low density lipoprotein-cholesterol (LDL-C) had significantly changed at DTx and ATx compared to BTx. In addition,HOMA-IR and HOMA-β were significantly changed at DTx in the SVR group. Among those with a high baseline insulinresistance (HOMA-IR >2.5), HOMA-IR was significantly changed at DTx in the SVR group. Conclusions: LDL-C appears to be associated with HCV treatment in SVR patients. Furthermore, eradication of HCVmay improve whole-body IR and insulin hypersecretion, as well as high baseline insulin resistance (HOMA-IR >2.5).

목차

등록된 정보가 없습니다.

참고문헌 (21)

참고문헌 신청

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0