지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 165 - 172 (8page)
이용수
초록· 키워드
오류제보하기
Background/Aims: Carnitine and vitamin complex (GodexⓇ) is widely used in patients with chronic liver disease who show elevated liver enzyme in South Korea. The purpose of this study is to identify the efficacy and safety of carnitine from entecavir combination therapy in Alanine aminotransferase (ALT) elevated Chronic Hepatitis B (CHB) patients.
Methods: 130 treatment-naïve patients with CHB were enrolled from 13 sites. The patients were randomly selected to the entecavir and the complex of entecavir and carnitine. The primary endpoint of the study is ALT normalization level after 12 months.
Results: Among the 130 patients, 119 patients completed the study treatment. The ALT normalization at 3 months was 58.9% for the monotherapy and 95.2% for the combination therapy (P<0.0001). ALT normalization rate at 12 months was 85.7% for the monotherapy and 100% for the combination group (P=0.0019). The rate of less than HBV DNA 300 copies/mL at 12 months was not statistically significant (P=0.5318) 75.9% for the monotherapy, 70.7% for the combination and it was. Quantification of HBsAg level was not different from the monotherapy to combination at 12 months. Changes of ELISPOT value to evaluate the INF-γ secretion by HBsAg showed the increasing trend of combination therapy compare to monotreatment.
Conclusions: ALT normalization rate was higher in carnitine complex combination group than entecavir group in CHB. Combination group was faster than entecavir mono-treatment group on ALT normalization rate. HBV DNA normalization rate and the serum HBV-DNA level were not changed by carnitine complex treatment. (Clin Mol Hepatol 2013;19:165-172)
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Athanassakis I / 2001 / L-carnitine modifies the humoral immune response in mice after in vitro or in vivo treatment / Int Immunopharmacol 1 : 1813 ~ 1822
Athanassakis I / 2003 / Early events of the exogenously provided L-Carnitine in murine macrophages, T- and B-lymphocytes: modulation of prostaglandin E1 and E2 production in
Bertelli A / 1993 / Protective action of L-carnitine and coenzyme Q10 against hepatic triglyceride infiltration induced by hyperbaric oxygen and ethanol / Drugs Exp Clin Res
Bykov I / 2003 / L-carnitine alleviates alcoholinduced liver damage in rats: role of tumour necrosis factor-alpha / Alcohol Alcohol 38 : 400 ~ 406
Chang TT / 2006 / A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B / N Engl J Med 354 : 1001 ~ 1010
Athanassakis I / 2003 / Early events of the exogenously provided L-Carnitine in murine macrophages, T- and B-lymphocytes: modulation of prostaglandin E1 and E2 production in
Bertelli A / 1993 / Protective action of L-carnitine and coenzyme Q10 against hepatic triglyceride infiltration induced by hyperbaric oxygen and ethanol / Drugs Exp Clin Res
Bykov I / 2003 / L-carnitine alleviates alcoholinduced liver damage in rats: role of tumour necrosis factor-alpha / Alcohol Alcohol 38 : 400 ~ 406
Chang TT / 2006 / A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B / N Engl J Med 354 : 1001 ~ 1010
이 논문의 저자 정보
최근 본 자료
댓글(0)
0