지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 130 - 138 (9page)
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Background/Aims:Several studies suggested that serum cystatin C (CysC) is more useful than serum creatinine (Cr) for the assessment of renal function in patients with liver cirrhosis. This study evaluated the clinical significance of CysC in patients with cirrhotic ascites and normal Cr level. Methods: We enrolled patients with cirrhotic ascites and a normal serum Cr level (<1.2 mg/dL). GFR was measured by ^(99m)Tc- DTPA renal scan. Serum Cr, CysC, and Cr clearance (CCr) were measured on the same day. Significant renal impairment and severe renal impairment were defined as GFR <60 mL/min and GFR <30 mL/min, respectively. Results: Eighty-nine patients with cirrhotic ascites were enrolled in the study (63 men and 26 women; age, 55±11 years). Forty-seven (52.8%) and 42 (47.2%) patients were in Child-Pugh grade B and C, respectively. Serum Cr and CysC levels and GFR were 0.8±0.2 mg/dL, 1.1±0.3 mg/L, and 73.4±25.5 mL/min, respectively. Significant and severe renal impairment were noted in 28 (31.5%) and 2 (2.2%) patients, respectively. GFR was well correlated with serum Cr, CysC, and e-GFRMDRD, while it was not correlated with e-GFRC&G. In multivariate analysis, only CysC was significantly correlated with GFR (β, 45.620; 95% CI, 23.042-68.198; P<0.001). Serum CysC level was the only independent predictor for significant renal impairment. Conclusions: Significant renal dysfunction was not rare in patients with cirrhotic ascites, even their serum Cr level is normal. Serum CysC is a useful marker for detecting significant renal dysfunction in these patients.
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참고문헌 (25)
참고문헌 신청
[학술지(정기간행
Arroyo V / 2003 / Ascites and hepatorenal syndrome in cirrhosis: pathophysiological basis of therapy and current management / J Hepatol 38 (1) : 69 ~ 89
Arroyo V / 2008 / Pathogenesis and treatment of hepatorenal syndrome / Semin Liver Dis 28 : 81 ~ 95
Cholongitas E / 2007 / Review article: renal function assessment in cirrhosis - difficulties and alternative measurements / Aliment Pharmacol Ther 26 : 969 ~ 978
Cockcroft DW / 1976 / Prediction of creatinine clearance from serum creatinine / Nephron 16 : 31 ~ 41
Arroyo V / 2003 / Ascites and hepatorenal syndrome in cirrhosis: pathophysiological basis of therapy and current management / J Hepatol 38 (1) : 69 ~ 89
Arroyo V / 2008 / Pathogenesis and treatment of hepatorenal syndrome / Semin Liver Dis 28 : 81 ~ 95
Cholongitas E / 2007 / Review article: renal function assessment in cirrhosis - difficulties and alternative measurements / Aliment Pharmacol Ther 26 : 969 ~ 978
Cockcroft DW / 1976 / Prediction of creatinine clearance from serum creatinine / Nephron 16 : 31 ~ 41
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