지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 149 - 153 (5page)
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초록· 키워드
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We report the case of a 14-year-old girl, diagnosed with atypical thrombotic microangiopathy (TMA). The patient presented with persistent fever, nausea,and newly developed peripheral edema. Her laboratory findings indicated chronic anemia with no evidence of hemolysis, thrombocytopenia, or elevated serum creatinine level. A few days after hospitalization, acute renal failure and fever worsened, and proteinuria developed. On day 40 of hospitalization,she experienced a generalized tonic seizure for 5 min, accompanied by renal hypertension. Brain magnetic resonance imaging revealed posterior reversible leukoencephalopathy syndrome. After steroid pulse therapy, a renal biopsy was performed because of delayed recovery from thrombocytopenia. The biopsy findings showed features of thrombotic microangiopathic hemolysis with fibrinoid change restricted. Current diagnostic criteria for TMA have focused on thrombotic thrombocytopenic purpura and hemolytic uremic syndrome,and diagnosis is based on the clinical presentation and etiology, with the consequence that idiopathic and atypical forms of TMA can be overlooked.
Developing effective tools to diagnose TMA, such as studying levels of ADAMTS13or testing for abnormalities in the complement system, will be the first step to improving patient outcomes.
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등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
Akashi Y / 1994 / Hemolytic uremic syndrome without hemolytic anemia: a case report / Clin Nephrol 42 : 90 ~ 94
Bahloul M / 2007 / Thrombotic microangiopathies. Incidence, pathogenesis, diagnosis, treatment and prognosis / J Mal Vasc 32 : 75 ~ 82
Brilliant SE / 1996 / Hemolytic-uremic syndrome without evidence of microangiopathic hemolytic anemia on peripheral blood smear / South Med J 89 : 342 ~ 345
Chapman K / 2012 / Thrombotic microangiopathies, thrombotic thrombocytopenic purpura, and ADAMTS- 13 / Semin Thromb Hemost 38 : 47 ~ 54
Coppo P / 2002 / Pathophysiology of thrombotic microangiopathies: current understanding / Ann Med Interne (Paris) 153 : 153 ~ 166
Bahloul M / 2007 / Thrombotic microangiopathies. Incidence, pathogenesis, diagnosis, treatment and prognosis / J Mal Vasc 32 : 75 ~ 82
Brilliant SE / 1996 / Hemolytic-uremic syndrome without evidence of microangiopathic hemolytic anemia on peripheral blood smear / South Med J 89 : 342 ~ 345
Chapman K / 2012 / Thrombotic microangiopathies, thrombotic thrombocytopenic purpura, and ADAMTS- 13 / Semin Thromb Hemost 38 : 47 ~ 54
Coppo P / 2002 / Pathophysiology of thrombotic microangiopathies: current understanding / Ann Med Interne (Paris) 153 : 153 ~ 166
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