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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 142 - 146 (5page)
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Purpose: Taurolidine is an antimicrobial agent that was originally used in the local treatment of peritonitis. The aim of this study was to evaluate the efficacy of taurolidine irrigation in primary total knee arthroplasty (TKA).Materials and Methods: All patients who underwent TKA at our institute from January 2015 to March 2017 were eligible. There were 300 patients in the taurolidine irrigation group and 300 patients in the control group. The patients in the taurolidine irrigation group were irrigated after implantation with a mix of 250 mL of taurolidine and 750 mL of normal saline. The patients in the control group were not irrigated after implantation. We compared postoperative Creactive protein (CRP), erythrocyte sedimentation rate (ESR), and infection rate between groups.Results: The taurolidine irrigation group had a significantly lower CRP (5.39 mg/dL vs. 7.55 mg/dL; p<0.001) and ESR (53.21 mm/hr vs. 58.74 mm/hr; p=0.003) on postoperative day 3 after TKA, as compared with the control group. However, there was no difference between the two groups on postoperative days 6, 13, and 20. Periprosthetic joint infection occurred in one patient in the taurolidine irrigation group.Conclusions: We believe that it is not necessary to use taurolidine for patients who undergo primary TKA.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Kurtz S / 2007 / Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030 / J Bone Joint Surg Am 89:780~785
Daines BK / 2015 / Infection prevention in total knee arthroplasty / J Am Acad Orthop Surg 23:356~364
Kaptanoglu L / 2008 / The effect of taurolidine on experimental thrombus formation / Eur J Pharmacol 578:238~241
Traub WH / 1993 / Taurolidine: in vitro activity against multiple-antibiotic-resistant, nosocomially significant clinical isolates of Staphylococcus aureus, Enterococcus faecium, and diverse Enterobacteriaceae / Chemotherapy 39:322~330
Willatts SM / 1995 / Effect of the antiendotoxic agent, taurolidine, in the treatment of sepsis syndrome: a placebo-controlled, double-blind trial / Crit Care Med 23:1033~1039
Daines BK / 2015 / Infection prevention in total knee arthroplasty / J Am Acad Orthop Surg 23:356~364
Kaptanoglu L / 2008 / The effect of taurolidine on experimental thrombus formation / Eur J Pharmacol 578:238~241
Traub WH / 1993 / Taurolidine: in vitro activity against multiple-antibiotic-resistant, nosocomially significant clinical isolates of Staphylococcus aureus, Enterococcus faecium, and diverse Enterobacteriaceae / Chemotherapy 39:322~330
Willatts SM / 1995 / Effect of the antiendotoxic agent, taurolidine, in the treatment of sepsis syndrome: a placebo-controlled, double-blind trial / Crit Care Med 23:1033~1039
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