지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 164 - 172 (9page)
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Purpose: To evaluate the treatment results of intraarticular injection according to the frequency of hyaluronic acid with mesenchymal stem cells on the osteochondral defect of rabbits’ medial femoral condyles.
Materials and Methods: A 5 mm diameter and 4 mm depth osteochondral defect was made on the medial femoral condyles of 18 rabbits, divided into six groups. One week after osteochondral defect, group B was injected intraarticularly with hyaluronic acid (HA), group C with mesenchymal stem cells (MSCs), and group D, E and F with both HA and MSCs. Group E and F received second HA injection a week after. Further, group F received third HA injection in the third week.
Results: In a macroscopic evaluation, groups B (6; range, 5-8), C (6; range, 6-7), D (7; range, 6-7), E (6.5; range, 6-8) and F (7.5; range, 6-8) showed statistically significant improvements in osteochondral defect healing, compared with that of group A (4; range, 3-5) (p=0.002). In histological evaluation, groups B (11.5; range, 11-13), C (13; range, 12-18), D (16; range, 13-18), E (17.5; range, 13-20), and F (19.5; range, 12-22) showed statistically significant differences in osteochondral defect healing, compared with group A (8; range, 6-9) (p=0.006).
Conclusions: The intraarticular injections of MSCs or HA can play an effective role during the healing osteochondral defects in rabbits.
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참고문헌 (23)
참고문헌 신청
Altman RD / 2000 / Intra-articular sodium hyaluronate in osteoarthritis of the knee / Semin Arthritis Rheum 30 : 11 ~ 8
Aroen A / 2004 / Articular cartilage lesions in 993 consecutive knee arthroscopies / Am J Sports Med 32 : 211 ~ 5
Badiavas EV / 2003 / Participation of bone marrow derived cells in cutaneous wound healing / J Cell Physiol 196 : 245 ~ 50
Barry FP / 2003 / Mesenchymal stem cell therapy in joint disease / Novartis Found Symp 249 : 86 ~ 96
Breinan HA / 1997 / Effect of cultured autologous chondrocytes on repair of chondral defects in a canine model / J Bone Joint Surg Am 79 : 1439 ~ 51
Aroen A / 2004 / Articular cartilage lesions in 993 consecutive knee arthroscopies / Am J Sports Med 32 : 211 ~ 5
Badiavas EV / 2003 / Participation of bone marrow derived cells in cutaneous wound healing / J Cell Physiol 196 : 245 ~ 50
Barry FP / 2003 / Mesenchymal stem cell therapy in joint disease / Novartis Found Symp 249 : 86 ~ 96
Breinan HA / 1997 / Effect of cultured autologous chondrocytes on repair of chondral defects in a canine model / J Bone Joint Surg Am 79 : 1439 ~ 51
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