지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 33 - 42 (10page)
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Purpose: To evaluate the analgesic effect, efficacy and safety of aceclofenac controlled release (CR) in patients with chronic knee osteoarthritis (OA).Materials and Methods: A total of 125 subjects with chronic knee OA were randomly divided into two groups: one group (n=62) was administered aceclofenac CR once daily and the other (n=63), aceclofenac immediate release (IR) twice a day for 4 weeks. A 100-mm visual analogue scale (VAS), Knee injury and Osteoarthritis Outcome Score (KOOS) and range of motoin (ROM) were evaluated as the outcome measures. To evaluate the safety of the drug, adverse events, vital signs, physical examination findings, clinical laboratory values and electrocardiographic findings were evaluated.Results: The VAS, KOOS and ROM were improved after 4 weeks of administration in both groups, but the differences between the two groups were not statistically significant. Significant differences between the two groups were not shown in the evaluation of the adverse events, vital sign, physical examination results, clinical laboratory values, and electrocardiography.Conclusions: The aceclofenac CR and aceclofenac IR were equally effective in patients with chronic knee OA and the clinical trial results didn’t show any significant difference in safety. The new aceclofenac CR formulation was found to be effective and safe with the practical advantage of once daily administration.
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참고문헌 (29)
참고문헌 신청
Paulson SK / 2000 / Metabolism and excretion of [(14)C]celecoxib in healthy male volunteers / Drug Metab Dispos 28:308~314
Turck D / 1996 / A review of the clinical pharmacokinetics of meloxicam / Br J Rheumatol 35(1):13~16
Roos EM / 1999 / WOMAC Osteoarthritis Index : additional dimensions for use in subjects with post-traumatic osteoarthritis of the knee : Western Ontario and MacMaster Universities / Osteoarthritis Cartilage 7:216~221
Roos EM / 1998 / Knee injury and Osteoarthritis Outcome Score(KOOS) : validation of a Swedish version / Scand J Med Sci Sports 8:439~448
Roos EM / 1998 / Knee Injury and Osteoarthritis Outcome Score(KOOS) : development of a self-administered outcome measure / J Orthop Sports Phys Ther 28:88~96
Turck D / 1996 / A review of the clinical pharmacokinetics of meloxicam / Br J Rheumatol 35(1):13~16
Roos EM / 1999 / WOMAC Osteoarthritis Index : additional dimensions for use in subjects with post-traumatic osteoarthritis of the knee : Western Ontario and MacMaster Universities / Osteoarthritis Cartilage 7:216~221
Roos EM / 1998 / Knee injury and Osteoarthritis Outcome Score(KOOS) : validation of a Swedish version / Scand J Med Sci Sports 8:439~448
Roos EM / 1998 / Knee Injury and Osteoarthritis Outcome Score(KOOS) : development of a self-administered outcome measure / J Orthop Sports Phys Ther 28:88~96
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