지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 191 - 195 (5page)
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Accumulated evidence indicate that Ginkgo biloba extract (EGb 761) acts as an antioxidant and scavenger of free radicals as well as influencing apoptotis. Earlier studies have employed the inflammatory agent lipopolysaccharide (LPS) to induce severe sepsis. In the present study, we examined whether the intraperitoneal injection of EGb 761 increases the survival rate of mice in the LPS-induced severe sepsis model. The survival rate was significantly increased by 30% in mice administered with 100 mg/kg of EGb 761 but not in mice administered with 50 mg/kg EGb 761. In addition, pre-treatment with EGb 761 increased the survival rate (30%) but post-treatment with EGb 761 did not. These results suggest that EGb 761 may have clinical potential in preventing sepsis induced mortality.
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등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Chen G. / 2005 / Suppression of HMGB1 release by stearoyl lysophosphatidylcholine: an additional mechanism for its therapeutic effects in experimental sepsis / J Lipid Res 46
Di Giantomasso D. / 2003 / Vital organ blood flow during hyperdynamic sepsis / Chest 124 : 1053 ~ 1059
Fink MP. / 2007 / Ethyl pyruvate: a novel treatment for sepsis / Curr Drug Targets 8 : 515 ~ 518
Freise H. / 2001 / Animal models of sepsis / J Invest Surg 14 : 195 ~ 212
Haines DD. / 2000 / Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/repe
Di Giantomasso D. / 2003 / Vital organ blood flow during hyperdynamic sepsis / Chest 124 : 1053 ~ 1059
Fink MP. / 2007 / Ethyl pyruvate: a novel treatment for sepsis / Curr Drug Targets 8 : 515 ~ 518
Freise H. / 2001 / Animal models of sepsis / J Invest Surg 14 : 195 ~ 212
Haines DD. / 2000 / Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/repe
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