지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 105 - 109 (5page)
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초록· 키워드
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Apoptosis is a host defense mechanism that the cell uses to limit production of infectious pathogens. Although many bacteria, viruses and parasites can induce apoptosis in infected cells, some pathogens usually exhibit the ability to suppress the induction of apoptosis in the infected cells. Sophisticated evasion strategies of obligate intracellular parasites, in particular prevention of host cell apoptosis, are necessary to ensure successful replication. To study the ability of Eimeria tenella in this regard, in vitro experiments were performed applying Madin-Darby bovine kidney (MDBK) cells as host cell. We have demonstrated that productive infection of adherent cell lines by E. tenella resulted in an anti-apototic effect. This phenomenon was confirmed using in situ terminal deoxynucleotidyl transferase- mediated (TdT) deoxyuridine triphosphates (dUTP)-fluorescein nick end labeling (TUNEL) assay to detect apoptosis. Therefore, E. tenella could complete its cycle of productive infection while inducing anti-apoptosis in the infected cells. This finding might have implications for the pathobiology of E. tenella and other Eimeria species.
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참고문헌 (24)
참고문헌 신청
Allen PC. / 1998 / Dietary modulation of avian coccidiosis / Int J Parasitol 28 : 1131 ~ 1140
Ameisen JC. / 1991 / Cell dysfunction in AIDS: the programmed cell death hypothesis / Immunol Today 12 : 102 ~ 105
Behrendt JH. / 2004 / Alternative mechanism of Eimeria bovis sporozoites to invade cells in vitro by breaching the plasma membrane / J Parasitol 90 : 1163 ~ 1165
Cheng EH. / 1997 / A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak / Proc Natl Acad
Cox FE. / 1998 / Control of coccidiosis: lessons from other sporozoa / Int J Parasitol 28 : 165 ~ 179
Ameisen JC. / 1991 / Cell dysfunction in AIDS: the programmed cell death hypothesis / Immunol Today 12 : 102 ~ 105
Behrendt JH. / 2004 / Alternative mechanism of Eimeria bovis sporozoites to invade cells in vitro by breaching the plasma membrane / J Parasitol 90 : 1163 ~ 1165
Cheng EH. / 1997 / A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak / Proc Natl Acad
Cox FE. / 1998 / Control of coccidiosis: lessons from other sporozoa / Int J Parasitol 28 : 165 ~ 179
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