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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 19 - 27 (9page)
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This study was conducted to investigate the antimicrobial resistance, presence of β-lactamase genes and integrons in 83 ESBL-producing Escherichia coli isolated from Nakdong river and Geumho river in Daegu. Among the β-lactam antimicrobials, all isolates were resistant to ampicillin, cephalothin, cefa-mandole and cefotaxime, followed by piperacillin (98.8%), ampicillin/sulbactam (86.7%), aztreonam (60.2%) and cefepime (59.0%), whereas resistance to piperacillin/tazobacram, ticarcillin/clavulanic acid and cefoxitin was less than 30%. Many of the ESBL-producing Escherichia coli were also resistant to non-β-lactams antimicrobials such as nalidixic acid (83.1%), sulfonamides (72.3%), ciprofloxacin (62.7%) and gentamicin (38.6%). All isolates showed resistance to seven or more antimicrobial agents. The most frequently detected gene was blaTEM+CTX-M (49.4%), followed by blaCTX-M (27.7%), blaTEM (6.0%) and blaOXA (1.2%). But blaSHV was not found. Class 1 integrons were found in 61.4% (51 iso-lates) of isolates, however, class 2 and 3 integrons were not detected. The results showed water from Nakdong river and Geumho river is contaminated with ESBL-producing E. coli isolates. These results suggest the need for further investigation of antibiotic resistant bacteria to prevent public health impacts in the water environment.
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참고문헌 (22)
참고문헌 신청
Ash RJ / 2002 / Antibiotic resistance of gramnegative bacteria in rivers, United States / Emerg Infect Dis 8 : 713 ~ 716
Baquero F / 2008 / Antibiotics and antibiotic resistance in water environments / Curr Opin Biotechnol 19 : 260 ~ 265
Bauer AW / 1966 / Antibiotic susceptibility testing by a standardized single disk method / Am J Clin Pathol 45 : 493 ~ 496
Belaaouaj A / 1994 / Nucleotide sequences of the genes coding for the TEM-like beta-lactamases IRT-1 and IRT-2 (formerly called TRI-1 and TRI-2) / FEMS Microbiol Lett 120 : 7
Bradford PA / 2001 / Extended-spectrum β-lactamases in the 21st century: Characterization, epidemiology, and detection of this important resistance threat / Clin Microbiol R
Baquero F / 2008 / Antibiotics and antibiotic resistance in water environments / Curr Opin Biotechnol 19 : 260 ~ 265
Bauer AW / 1966 / Antibiotic susceptibility testing by a standardized single disk method / Am J Clin Pathol 45 : 493 ~ 496
Belaaouaj A / 1994 / Nucleotide sequences of the genes coding for the TEM-like beta-lactamases IRT-1 and IRT-2 (formerly called TRI-1 and TRI-2) / FEMS Microbiol Lett 120 : 7
Bradford PA / 2001 / Extended-spectrum β-lactamases in the 21st century: Characterization, epidemiology, and detection of this important resistance threat / Clin Microbiol R
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