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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제16권 제2호
- 발행연도
- 2012.1
- 수록면
- 136 - 141 (6page)
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초록· 키워드
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Purpose : To investigate the pharmacologic modulation of motor task-dependent physiologic responses by antiplatelet agent, clopidogrel, during hand motor tasks in healthy subjects.
Materials and Methods: Ten healthy, right-handed subjects underwent three functional magnetic resonance (fMRI) sessions:one before drug administration, one after high dose drug administration and one after reaching drug steady state.
For the motor task fMRI, finger flexion-extension movements were performed. Blood oxygenation level dependent (BOLD)contrast was collected for each subject using a 3.0 T VHi (GE Healthcare, Milwaukee, USA) scanner. T2*-weighted echo planar imaging was used for fMRI acquisition. The fMRI data processing and statistical analyses were carried out using SPM2.
Results: Second-level analysis revealed significant increases in the extent of activation in the contralateral motor cortex including primary motor area (M1) after drug administration. The number of activated voxels in motor cortex was 173without drug administration and the number increased to 1049 for high dose condition and 673 for steady-state condition respectively. However, there was no significant difference in the magnitude of BOLD signal change in terms of peak T value.
Conclusion: The current results suggest that cerebral motor activity can be modulated by clopidogrel in healthy subjects and that fMRI is highly senstive to evidence such changes.
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참고문헌 (20)
참고문헌 신청
Bozzali M / 2006 / Left prefrontal cortex control of novel occurrences during recollection: a psychopharmacological study using scopolamine and eventrelated fMRI / Neuroimag
Braus D / 1999 / Antipsychotic drug effects on motor activation measured by functional magnetic resonance imaging in schizophrenic patients / Schizophr Res 39 : 19 ~ 29
Chan F / 2005 / Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding / New Engl J Med 352 : 238 ~ 244
Evans A / 1993 / 3D statistical neuroanatomical models from 305 MRI volumes / Proc. IEEE-Nucl. Sci. Symp. Med. Imaging : 1813 ~ 1817
Friston K / 1995 / Statistical parametric paps in functional imaging: a general linear approach / Hum Brain Mapp 2 : 189 ~ 210
Braus D / 1999 / Antipsychotic drug effects on motor activation measured by functional magnetic resonance imaging in schizophrenic patients / Schizophr Res 39 : 19 ~ 29
Chan F / 2005 / Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding / New Engl J Med 352 : 238 ~ 244
Evans A / 1993 / 3D statistical neuroanatomical models from 305 MRI volumes / Proc. IEEE-Nucl. Sci. Symp. Med. Imaging : 1813 ~ 1817
Friston K / 1995 / Statistical parametric paps in functional imaging: a general linear approach / Hum Brain Mapp 2 : 189 ~ 210
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