지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
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- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제7권 제1호
- 발행연도
- 2014.1
- 수록면
- 1 - 6 (6page)
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Objectives. To examine the expression profile of Fas-Fas ligand (FasL) during glutamate (Glu)-induced spiral ganglion cell (SGC) apoptosis.
Methods. Cultured SGCs were treated with 10-mM, 25-mM, and 50-mM concentrations of Glu and incubated for 24 or 48 hours. The expression intensity of FasL, Fas, caspase 3, and morphology of single SGC were evaluated using immu- nofluorescence staining.
Results. In semiquantitative analysis of the Glu-treated SGC, FasL, and caspase 3 expression intensity were increased with concentration- and time-dependent manner. Fas expression intensity did not change with different concentration at 48 hours. In morphologic analysis of the Glu-treated SGC, number of apoptotic cells were increased with concentra- tion- and time-dependent manner.
Conclusion. FasL was expressed in apoptotic SGCs, suggesting that the Fas-FasL signaling pathway may be involved in the Glu-induced apoptosis of dissociated SGCs.
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참고문헌 (20)
참고문헌 신청
Alam SA / 2000 / Cisplatin-induced apoptotic cell death in Mongolian gerbil cochlea / Hear Res 141 (1-2) : 28 ~ 38
Alam SA / 2001 / The expression of apoptosis-related proteins in the aged cochlea of Mongolian gerbils / Laryngoscope 111 (3) : 528 ~ 534
Bae WY / 2008 / Secondary apoptosis of spiral ganglion cells induced by aminoglycoside: Fas-Fas ligand signaling pathway / Laryngoscope 118 (9) : 1659 ~ 1668
Janssen R / 1991 / Glutamate neurotoxicity in the developing rat cochlea: physiological and morphological approaches / Brain Res 552 (2) : 255 ~ 264
Jeong SW / 2010 / Gentamicin-induced spiral ganglion cell death: apoptosis mediated by ROS and the JNK signaling pathway / Acta Otolaryngol 130 (6) : 670 ~ 678
Alam SA / 2001 / The expression of apoptosis-related proteins in the aged cochlea of Mongolian gerbils / Laryngoscope 111 (3) : 528 ~ 534
Bae WY / 2008 / Secondary apoptosis of spiral ganglion cells induced by aminoglycoside: Fas-Fas ligand signaling pathway / Laryngoscope 118 (9) : 1659 ~ 1668
Janssen R / 1991 / Glutamate neurotoxicity in the developing rat cochlea: physiological and morphological approaches / Brain Res 552 (2) : 255 ~ 264
Jeong SW / 2010 / Gentamicin-induced spiral ganglion cell death: apoptosis mediated by ROS and the JNK signaling pathway / Acta Otolaryngol 130 (6) : 670 ~ 678
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