A Polymorphism (rs1801018, Thr7Thr) of BCL2 is Associated with Papillary Thyroid Cancer in Korean Population

은영규; 홍일기; 김수강; 박현경; 권삼; 정대한; 권기환

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자료유형: 학술저널

저자정보: 은영규 홍일기 김수강 박현경 권삼 정대한 권기환

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제4권 제3호

발행연도: 2011.1

수록면: 149 - 154 (6page)

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Objectives. Among the apoptosis signals, B-cell CLL/lymphoma 2 (BCL2) is a well-known regulator of apoptosis with antiapoptotic properties. We investigated here whether single nucleotide polymorphisms (SNPs) of the BCL2 were associated with host susceptibility of papillary thyroid cancer (PTC) occurrence and clinicopathologic parameters. Methods. Ninety-two PTC patients and 222 control subjects were recruited. One promoter SNP (rs2279115, -938A/C) and one synonymous SNP (rs1801018, Thr7Thr) in the BCL2 gene were selected and genotyped using direct sequencing. Multiple logistic regression models were performed to evaluate odds ratios, 95% confidence intervals, and P-values. Results. rs1801018 of the BCL2 gene was not associated with the development of PTC. In the clinicopathologic features,rs1801018 SNP was associated with the number and location. The G allele frequency of rs1801018 in PTC patients with multifocality (13.3%) was about four-fold higher than that in PTC patients with unifocality (3.4%). The G allele frequency of rs1801018 in PTC patients with both lobes (15.4%) was increased by about five-fold, compared to PTC patients with one lobe (3.2%). Conclusion. The results suggest that synonymous SNP rs1801018 and the G allele of the BCL2 gene may be associated with the multifocality and bilaterality of PTC in Korean population.

#BCL2 #Polymorphism #Haplotype #Thyroid cancer #Papillary

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[학술지(정기간행물)

/ / National Cancer Information Center. National cancer statistics [Internet] / Goyang: National Cancer Center

Bachmann HS / 2007 / The AA genotype of the regulatory BCL2 promoter polymorphism ( 938C>A) is associated with a favorable outcome in lymph node negative invasive breast

Bachmann HS / 2011 / Regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinoma / Int J Cancer

Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21 (2) : 263 ~ 265

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소속기관 경희대학교 의과대학 이비인후과학교실

주요연구분야 의약학 > 의학 일반 의약학 > 임상의학 > 이비인후과학

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