분절된 튜브의 기도 내 삽입에 의한 기도협착 동물 모델

임수진; 김성원; 이강대; 김서빈; 전석원; 옥철호; 정민정; 황치우; 이형신

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자료유형: 학술저널

저자정보: 임수진 김성원 이강대 김서빈 전석원 옥철호 정민정 황치우 이형신

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제59권 제8호

발행연도: 2016.1

수록면: 599 - 603 (5page)

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Background and Objectives Various methods to induce tracheal stenosis in an animal model have been introduced. However, most methods use non-physiologic mechanical or chemical injury to tracheal mucosa or cartilage. In this study, we sought to develop an animal model of tracheal stenosis using a segmented endotracheal tube. Materials and Method Nine New Zealand White Rabbits were included in this feasibility study. A segmented 1.5 cm LEVIN-Tube (16 French) was inserted into tracheal lumen via tracheotomy site and fixed with a nylon tape circumferentially tied around the trachea. The tube was removed transorally one week later and the tracheal lumen was observed with bronchoscopy every week. Rabbits were sacrificed two weeks after the tube removal and the trachea was evaluated with histologic image. Three rabbits underwent tracheotomy and closure only to evaluate possible impact of tracheotomy procedure to tracheal stenosis (sham surgery). Results None of the 6 rabbits showed significant complications or death during the study. No significant change of tracheal lumen was identified in 3 sham models. The mean grade of stenosis was 57.2±9.9% (range, 43-70%). Histologic image showed thickening and fibrosis of lamina propria with relatively intact tracheal cartilage framework. Conclusion We developed an animal model of tracheal stenosis using a segmented endotracheal tube fixed with a nylon tape. Since this model has similar pathophysiology to prolonged endotracheal intubation, it may be used in various studies related to tracheal stenosis. Korean J Otorhinolaryngol-Head Neck Surg 2016;59(8):599-603

#Animal model ㆍEndotracheal intubation ㆍTrachea ㆍTracheal stenosis.

참고문헌 (19)

참고문헌 신청

정미영 / 2011 / 기관내 삽관 후 환형의 기관 갈퀴막 형성으로 인한 기도 폐쇄 -증례 보고- / Anesthesia and Pain Medicine 6(4):349~352

백정환 / 2003 / 고도의 후두기관 협착증에 대한 갑상기관 단단문합술 / 대한이비인후과학회지 두경부외과학 46(7):586~591

조형호 / 2003 / 후두기관 협착증에 대한 확대 후두기관 성형술 / 대한이비인후과학회지 두경부외과학 46(9):775~779

Han CJ / 2001 / Treatment of thoracic tracheal stenosis by sternotomy approach / Korean J Otolaryngol-Head Neck Surg 44(7):758~762

Choi HY / 1999 / Thyrotracheal anastomosis for combined laryngotracheal stenosis:experience in 11 cases / Korean J Otolaryngol 42(11):1441~1446

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