지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제7권 제4호
- 발행연도
- 2014.1
- 수록면
- 241 - 249 (9page)
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초록· 키워드
오류제보하기
Allergic rhinitis (AR) is a globally increasing health problem affecting the quality of life. Specific immunotherapy is an available causal treatment changing the basic allergic mechanisms of the disease. Over one hundred years, subcutaneous immunotherapy (SCIT) was developed and proved its efficacy but many adverse effects were recorded including anaphy- laxis. In 1986, sublingual immunotherapy (SLIT) was introduced as an alternative solution to solve this problem. Our study aims to discuss SLIT from the points of efficacy, safety, adherence and guidelines developed. A literature search was con- ducted in Medline/PubMed and the Cochrane Library in January 2013 using the keywords “allergic rhinitis, sublingual im- munotherapy, efficacy, safety, compliance, adherence, guidelines.” All types of publications were included. We augmented our study by searching the reference lists of identified reviews. SLIT has been established in many guidelines as an evi- dence-based effective treatment in AR with safer profile than SCIT. The meta-analyses confirmed its efficacy and showed a significant reduction in both symptoms and medication scores. The most common recorded adverse effects were minor lo- cal effects in the mouth, gastrointestinal reactions with few cases of anaphylaxis and no fatality. Adherence is more favor- able for SLIT mainly because it is safe, noninvasive and easily taken at home. We support the call to conduct large multi- centric studies to gain more statistical power and overcome the problem of heterogeneity observed in the meta-analyses.
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참고문헌 (24)
참고문헌 신청
Amar SM / 2009 / Response to sublingual immunotherapy with grass pollen extract: monotherapy versus combination in a multiallergen extract / J Allergy Clin Immunol 124 (1) :
Bahceciler NN / 2005 / Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites / Int Arch Allergy Immunol 136 (3) :
Bousquet J / 1998 / Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper / J Allergy Clin Immunol 102 (4 Pt 1) : 558 ~ 562
Bousquet J / 2008 / Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen) / Allergy 63 (Sup
Brozek JL / 2010 / Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision / J Allergy Clin Immunol 126 (3) : 466 ~ 476
Bahceciler NN / 2005 / Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites / Int Arch Allergy Immunol 136 (3) :
Bousquet J / 1998 / Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper / J Allergy Clin Immunol 102 (4 Pt 1) : 558 ~ 562
Bousquet J / 2008 / Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen) / Allergy 63 (Sup
Brozek JL / 2010 / Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision / J Allergy Clin Immunol 126 (3) : 466 ~ 476
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