지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 603 - 609 (7page)
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초록· 키워드
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Background and Objectives Glucocorticoids are a potent anti-inflammatory agent. The au-thors conducted this study to investigate the effect of Omnaris® on suppression of inflammation induction and mucin gene expression in nasal polyp epithelial cells.
Subjects and Method Primary nasal polyp epithelial cells were stimulated by 5 ug/mL of streptococcal enterotoxin B (SEB) and lipopolysaccharide (LPS). To determine the effects of Omnaris®, cells were pretreated with 200, 100, 10, 1 ng/mL of Omnaris®. The anti-inflammatory effect of epithelial cells were confirmed by measuring interleukin (IL)-6, IL-8, and granulocyte-macrophage colony stimulating factor (GM-CSF), and mucin gene expressions were determined by real time PCR for MUC4, MUC5AC, MUC5B, MUC8.
Results SEB and LPS enhanced the production of IL-6, IL-8, and GM-CSF from nasal polyp epithelial cells. The increased cytokine levels were significantly suppressed by Omnaris® at 100 and 10 ng/mL. The expressions of MUC4, MUC5AC, MUC5B, MUC8 mRNA, and MUC4 mRNA were increased by SEB and LPS, respectively. The increased expression of these mucin genes were significantly suppressed by 100, 10, and 1 ng/mL of Omnaris®.
Conclusion Omnaris® significantly suppressed the production of chemical mediators and mucin gene expression, which indicated that Omnaris® is effective in improving and treating inflammatory diseases in the nasal cavity.
Korean J Otorhinolaryngol-Head Neck Surg 2014;57(9):603-9
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참고문헌 (19)
참고문헌 신청
Chen Y / 2006 / Dexamethasone-mediated repression of MUC5AC gene expression in human lung epithelial cells / Am J Respir Cell Mol Biol 34 (3) : 338 ~ 347
Derendorf H / 2006 / Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma / Eur Respir J 28 (5) : 1042 ~ 1050
Dostert A / 2004 / Negative glucocorticoid receptor response elements and their role in glucocorticoid action / Curr Pharm Des 10 (23) : 2807 ~ 2816
Fokkens WJ / 2012 / European Position Paper on Rhinosinusitis and Nasal Polyps 2012 / Rhinol Suppl (23) : 1 ~ 298
Homma T / 2004 / Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells / Am J Respir Cell Mol Biol 31 (4) : 46
Derendorf H / 2006 / Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma / Eur Respir J 28 (5) : 1042 ~ 1050
Dostert A / 2004 / Negative glucocorticoid receptor response elements and their role in glucocorticoid action / Curr Pharm Des 10 (23) : 2807 ~ 2816
Fokkens WJ / 2012 / European Position Paper on Rhinosinusitis and Nasal Polyps 2012 / Rhinol Suppl (23) : 1 ~ 298
Homma T / 2004 / Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells / Am J Respir Cell Mol Biol 31 (4) : 46
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