조기 성문암의 치료 전 Fluorodeoxyglucose-Positron Emission Tomography/  Computed Tomography(FDG-PET/CT)의 역할

송찬일; 한명월; 이윤세; 김상윤; 최승호; 남순열

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자료유형: 학술저널

저자정보: 송찬일 한명월 이윤세 김상윤 최승호 남순열

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제53권 제7호

발행연도: 2010.1

수록면: 419 - 424 (6page)

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Background and Objectives Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) has been widely used to detect regional and distant metastasis or second primary cancers at initial evaluation. The aim of this study was to evaluate the role of combined FDG-PET/CT in detecting early glottic cancers, which has low incidence of regional or distant metastasis. Subjects and Method We enrolled in our study 551 patients who had previously untreated glottic cancer between 2001 and 2008. Of these, 124 patients with early glottic cancer underwent FDG-PET/CT. Retrospectively, we compared the detection rates of regional, distant metastasis or second primary cancer by FDG-PET/CT with those after neck computed tomography (CT),chest X-ray, and liver sonography. Results In detecting regional metastasis, the sensitivity and specificity of FDG-PET/CT were 66.67% and 97.25%, respectively, with the positive predictive value (PPV) of 40%, the negative predictive value (NPV) of 99.16%, and the accuracy of 96.77%. The sensitivity, specificity, PPV,NPV and accuracy of neck CT were 66.67%, 96.69%, 33.33%, 99.15%, and 95.96%, respectively. The suspicious distant metastasis (n=1) and second primary cancers (n=7) were observed in FDG-PET/CT. The true second primary cancers occurred at the colon (n=1) and the prostate (n=2). The other cases were proved to be false positive. Distant metastasis and second primary cancers were not detected by the conventional work-up tests. Conclusion The regional metastasis detection rate of FDG-PET/CT was similar to those of the conventional work-up tests. However, compared to the conventional tests, FDG-PET/CT is useful for detecting distant metastasis or second primary cancers in patients with early glottic cancer. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:419-24

#Positron-emission tomography/computed tomography·Larynx cancer·Neoplasm metastasis·Second primary neoplasm.

참고문헌 (21)

참고문헌 신청

Adams S / 1998 / Prospective comparison of 18F-FDG PET with conventional imaging modalities (CT, MRI, US) in lymph node staging of head and neck cancer / Eur J Nucl Med 25 (

Brouwer J / 2005 / Screening for distant metastases in patients with head and neck cancer: is chest computed tomography sufficient? / Laryngoscope 115 (10) : 1813 ~ 1817

Brouwer J / 2006 / Screening for distant metastases in patients with head and neck cancer: is there a role for (18)FDG-PET? / Oral Oncol 42 (3) : 275 ~ 280

Choi JY / 2005 / Improved detection of second primary cancer using integrated [18F] fluorodeoxyglucose positron emission tomography and computed to mography for initial tumo

Conti PS / 1996 / Bading JR. PET and [18F]-FDG in oncology: a clinical update / Nucl Med Biol 23 (6) : 717 ~ 735

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