단광자방출단층촬영술을 이용한 언어습득 후 전농 환자군에서의  국소뇌혈류 변화 연구: Preliminary Study

한민아; 여상원; 양동원; 정용안; 박경호; 최혁기; 김성훈; 박시내

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자료유형: 학술저널

저자정보: 한민아 여상원 양동원 정용안 박경호 최혁기 김성훈 박시내

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제9호

발행연도: 2009.1

수록면: 724 - 729 (6page)

이용수

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연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

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Background and Objectives Cochlear implantation improves hearing ability in adults with profound deafness. Using non-invasive functional brain imaging methods, it is now possible to assess regional blood flow and activity of auditory cortex which might be correlated to the outcome of cochlear implantation. The aim of this study was to measure the regional cerebral blood flow in patients with postlingual deafness utilizing controls in a variety of methods. Subjects and Method Six postlingual deaf adults who were planned to undertake cochlear implantation and 12 normal controls were examined with technetium-99m-labeled ethyl cysteinate dimer single-photon emission computed tomography (99mTc-ECD-SPECT). Images of the regional cerebral blood flow were processed by statistical parametric mapping and analyzed by unpaired t-test. Results The analysis of the SPECT images of the 6 deaf patients showed decreased cerebral blood flow in both superior, middle temporal and inferior prefrontal lobes compared with controls (p<0.001). Also this decreased auditory cortical blood flow was greater in left hemisphere in all patients. Conclusion The degree of remaining activity of auditory cortex and the lateralization of the dominant auditory hemisphere, which may influence on the outcome of cochlear implantation, could be measured by ECD-SPECT.

#Auditory cortex·Deaf·Postlingual·ECD-SPECT·Cochlear implantation

참고문헌 (20)

참고문헌 신청

Allen A / 2004 / Perfusion SPECT in cochlear implantation and promontory stimulation / Nucl Med Commun 25 (5) : 521 ~ 525

Bartsch AJ / 2007 / Scanning for the scanner: FMRI of audition by read-out omissions from echo-planar imaging / Neuroimage 35 (1) : 234 ~ 243

Clarke S / 1998 / Compartments within human primary auditory cortex: evidence from cytochrome oxidase and acetylcholinesterase staining / Eur J Neurosci 10 (2) : 741 ~ 745

Coez A / 2008 / Cochlear implant benefits in deafness rehabilitation:PET study of temporal voice activations / J Nucl Med 49 (1) : 60 ~ 67

Galaburda A / 1980 / Cytoarchitectonic organization of the human auditory cortex / J Comp Neurol 190 (3) : 597 ~ 610

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