편도적출술 후 투여한 Rofecoxib가 통증 및 출혈에 미치는 효과

이승균; 김명원; 조정해; 김규백; 박용수; 황성재; 전은주

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자료유형: 학술저널

저자정보: 이승균 김명원 조정해 김규백 박용수 황성재 전은주

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제47권 제12호

발행연도: 2004.1

수록면: 1,297 - 1,301 (5page)

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Background and Objectives：Nonsteroidal anti-inflammatory durgs (NSAIDs) are now widely accepted analgesics for posttonsillectomy patients, but their ability to inhibit platelet cyclooxygenase (COX) may be associated with a risk of increased bleeding after tonsillectomy. Rofecoxib, the recently introduced selective COX-2 inhibitor, may have advantages for analgesics in tonsillectomy in that they produce minimal effects on platelet aggregation. But the analgesic efficacy of rofecoxib in tonsillectomy has not been made known yet. The aim of our randomized prospective study was to compare the analgesic efficacy of rofecoxib, the selective COX-2 inhibitor, and ibuprofen, the classic NSAID, for the posttonsillectomy pain management. We also evaluated the influence of both drugs on the posttonsillectomy bleeding. Subjects and Method：Thirty-eight adult patients undergoing tonsillectomy were randomly divided into either ibuprofen or rofecoxib group. Patients received either oral ibuprofen (600 mg, three times a day) or oral rofecoxib (25 mg, twice a day). Patients recorded pain levels twice daily for 7 days using a visual analogue scale. Posttonsillectomy hemorrhage was recorded in each groups. Results：Pain scores for the 7 days were not significantly different between two groups, but the rofecoxib group reported less pain. Rofecoxib group felt more satisfactorily about early control of postoperative pain. There was no significant difference in the incidence of postoperative hemorrhage between two groups. Conclusion：Rofecoxib is as effective as ibuprofen for postoperative pain control in adult tonsillectomy, which might be beneficial for avoiding the adverse effects of NSAIDs.

#편도적출술·진통제· #Tonsillectomy· Analgesics· Ibuprofen· Rofecoxib.

참고문헌 (18)

참고문헌 신청

/ 1991 / Non-steroidal anti-inflammatory drugs:Rationalefor use in severe postoperative pain 66 : 703 ~ 712

/ 1995 / Perioperative ketorolac tromethamineand postoperative hemorrhage in cases of tonsillectomyand adenoidectomy 105 : 606 ~ 609

/ 1996 / Intraoperative ketorolac andposttonsillectomy bleeding 122 : 937 ~ 940

/ 1997 / A comparison ofibuprofen versus acetaminophen with codeine in the young tonsillectomypatient 117 : 76 ~ 82

/ 1998 / Ibuprofen for tonsillectomy pain in children:Efficacy and complications 119 : 492 ~ 496

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