Analysis of P1 Latency in Normal Hearing and Profound Sensorineural Hearing Loss

장정훈; 장훈경; 김성은; 오성하; 장선오; 이준호

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자료유형: 학술저널

저자정보: 장정훈 장훈경 김성은 오성하 장선오 이준호

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제3권 제4호

발행연도: 2010.1

수록면: 194 - 198 (5page)

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Objectives. P1 is a robust positivity at a latency of 50-150 msec in the auditory evoked potential of young children. It has been reported that over the first 2-3 years of life, there is a rapid decrease of the latency and the mean P1 latency in adults with normal hearing is approximately 60 msec. This study was designed to evaluate the change of the P1 latency in Koreans with normal hearing according to age and to compare this with the P1 latency of young patients with profound sensorineural hearing loss before and/or after cochlear implantation. Methods. Among the patients who visited the Department of Otorhinolaryngology at Seoul National University Hospital from June 2007 to September 2009, the P1 response was recorded in 53 patients in the normal hearing group, in 13patients in the pre-cochlear implantation (CI) group and in 10 patients in the post-CI group. A synthesized consonantvowel syllable /ba/ was used to elicit the evoked responses. The evoked responses were collected using the center of the frontal head. For each subject, an individual grand average waveform was computed by averaging the ten recordings. The P1 latency was visually identified as a robust positivity in the waveform. Results. For the normal hearing group, the P1 latency showed the pattern of shortening as the age increased (coefficient,-0.758; P<0.001). For the pre-CI group, 10 cases showed delayed latencies and 3 cases did not show the P1 wave. For the post-CI group, the P1 latencies showed a less delayed tendency than those of the pre-CI group, but this was not statistically different. Conclusion. This report provides the standard value of the P1 latency at each age in Koreans for the first time and the findings support that the maturation of the central auditory pathways could be measured objectively using the P1 latency.

#Auditory evoked potentials #Auditory pathways #Cochlear implantation

참고문헌 (16)

참고문헌 신청

Ceponiene R / 1998 / Interstimulus interval and auditory event-related potentials in children:evidence for multiple generators / Electroencephalogr Clin Neurophysiol 108 (4)

Cunningham J / 2000 / Speech-evoked neurophysiologic responses in children with learning problems:development and behavioral correlates of perception / Ear Hear 21 (6) : 554

Dorman MF / 2007 / Central auditory development:evidence from CAEP measurements in children fit with cochlear implants / J Commun Disord 40 (4) : 284 ~ 294

Kaas JH / 1999 / Auditory processing in primate cerebral cortex / Curr Opin Neurobiol 9 (2) : 164 ~ 170

Kraus N / 1985 / Auditory middle latency responses in children:effects of age and diagnostic category / Electroencephalogr Clin Neurophysiol 62 (5) : 343 ~ 351

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주요연구분야 의약학 > 의학 일반 의약학 > 임상의학 > 이비인후과학

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소속기관 대한이비인후과학회