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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 259 - 264 (6page)
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Lymph node metastasis (LNM) is an important prognostic factor in head and neck cancer (HNC), which leads to recurrence and poor outcome. Despite the advances in multimodality treatment protocols, overall survival in patients with LNM remains limited, thus calling for the need of a more thorough understanding of the biology in metastatic process. In the past, LNM had been suspected to rely mostly on passive mechanistic impulse from primary tumor. However, recent discovery of new lymphatic markers, regulating growth factors, and cognate receptors, has elucidated the active biological regulation during metastatic cascades, which primarily involves primary tumor lymphangiogenesis, pre-metastatic niche formation, and sentinel LNM. In this review, we discuss recent literatures on the mechanisms of LNM in HNC that is expected to allow a better understanding of the disease as well as suggesting a potential clinical implication. Korean J Otorhinolaryngol-Head Neck Surg 2016;59(4):259-64
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참고문헌 (50)
참고문헌 신청
Pantel K / 2004 / Dissecting the metastatic cascade / Nat Rev Cancer 4(6):448~456
Leemans CR / 1993 / Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma / Cancer 71(2):452~456
Cerezo L / 1992 / Prognostic factors for survival and tumor control in cervical lymph node metastases from head and neck cancer. A multivariate study of 492 cases / Cancer 69(5):1224~1234
Le Tourneau C / 2005 / Prognostic indicators for survival in head and neck squamous cell carcinomas: analysis of a series of 621 cases / Head Neck 27(9):801~808
장전엽 / 2016 / Prediction of Lymph Node Metastasis by Tumor Dimension Versus Tumor Biological Properties in Head and Neck Squamous Cell Carcinomas / Cancer Research and Treatment 48(1):54~62
Leemans CR / 1993 / Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma / Cancer 71(2):452~456
Cerezo L / 1992 / Prognostic factors for survival and tumor control in cervical lymph node metastases from head and neck cancer. A multivariate study of 492 cases / Cancer 69(5):1224~1234
Le Tourneau C / 2005 / Prognostic indicators for survival in head and neck squamous cell carcinomas: analysis of a series of 621 cases / Head Neck 27(9):801~808
장전엽 / 2016 / Prediction of Lymph Node Metastasis by Tumor Dimension Versus Tumor Biological Properties in Head and Neck Squamous Cell Carcinomas / Cancer Research and Treatment 48(1):54~62
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